NK/T-cell lymphoma (NKTCL) is characterized by the expression of the NK-cell antigen CD56. Non-nasal NK/T-cell lymphomas are subdivided into primary cutaneous and 4 subtypes of secondary cutaneous lymphomas; nasal type, aggressive, blastic (blastoid), and other specific NK-like cell lymphoma. Aggressive NK/T-cell lymphoma/leukemia is a rare leukemic variant of nasal type NKTCL. We herein report...

Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT), is a rare and aggressive variant of extranodal lymphoma. We report the case 64-year-old woman with unilateral lymphedema lower limb as first only symptom PCDLBCL-LT for six months. Violaceous nodules were second they progressively developed on edematous calf. Initially, diagnosed warty overgrowths, which are common skin cha...

  Primary Hepatic Lymphoma (PHL) is rare and possibly associated with viral hepatitis and autoimmune diseases. Scleroderma could exceptionally be complicated by lymphoma. We describe PHL occurring in a 52-year-old female suffering scleroderma for eight years, with no history of cytotoxic or high-dose glucocorticoid therapy. CT scan, performed to work-up abdominal discomfort, constipation, and ...

Primary cutaneous follicle center lymphoma (PCFCL) is the most common B-cell lymphoma. The typical immunophenotype includes expression of both CD20 and BCL6, with majority cases lacking CD10, BCL2, characteristic t(14;18)/IGH-BCL2 rearrangement seen in systemic follicular (FL). Plasmacytic differentiation (PD) an uncommon finding FLs presents a diagnostic challenge when present, leading to pote...

We describe a patient with primary cutaneous small-tomedium--sized CD4+ T-cell lymphoma, according to the most recent World Health Organization (WHO) classification of cutaneous lymphomas. This lymphoma, previously known as primary cutaneous small-to-medium-sized pleomorphic CD4+ T-cell lymphoma, has a low incidence and good prognosis. The interest in the case presented in this report derives f...

Efficient vaccination can be achieved by injections of in vitro transcribed mRNA (ivt mRNA) coding for antigens. This vaccine format is particularly versatile and allows the production individualised vaccines conferring, T-cell immunity against specific cancer mutations. The CDR3 hypervariable regions immune receptors (T-cell receptor, TCR or B-cell BCR) context T- leukaemia lymphoma are target...

Cutaneous T-cell lymphoma describes a heterogeneous group of neoplasms of skin homing T cells that vary considerably in clinical presentation, histologic appearance, immunophenotype, and prognosis. This paper addresses the cutaneous T-cell lymphoma in Asians with respect to clinical-epidemiologic and histopathological features. Compared with Western countries, Asia usually has higher rates of c...

Aberrant expression of microRNAs is widely accepted to be pathogenetically involved in nodal diffuse large B-cell lymphomas (DLBCLs). However, the microRNAs profiles of primary cutaneous large B-cell lymphomas (PCLBCLs) are not yet described. Its two main subtypes, i.e., primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL-LT) and primary cutaneous follicle center lymphoma (PCFCL) ...

colorectal lymphoma is an extremely rare disease, representing less than 0.5% of all primary colorectal neoplasms. the disease is usually diagnosed in the advanced stages because of its primary non-specific symptoms. the most common involved site is cecum followed by rectum and ascending colon. diffuse large b-cell lymphoma is a more frequent subtype. although surgical resection is often techni...

Cutaneous lymphomas comprise a heterogeneous group of lymphoproliferative disorders with skin involvement and are classified as a subgroup of non-Hodgkin lymphomas. From 1981 to 2007, 100 children with non-Hodgkin lymphomas were admitted to the Hematology Unit of the Federal University of Minas Gerais Teaching Hospital. In nine of these children, the skin was involved at the onset of the diseas...