A neoplastic mass compressing the left cerebellar hemisphere and hindbrain was observed at trimming in a 3½-year-old male cynomolgus monkey from a control dose group. Microscopically, the neoplastic mass was nonencapsulated, invasive, and showed two morphological patterns. The predominant area consisted of densely packed undifferentiated, polygonal to spindle cells arranged in vague shee...

Objective To investigate the clinicopathological feature, immunological phenotype, therapy and prognosis of primary renal primitive neuroectodermal tumor (primitive neuroectodermal tumor, PNET). Method To report diagnose and treat condition of a child with renal PNET and review relevant literature. Result The male patient aged 13 years old. Color-ultrasound found 3.5 cm × 3.0cm mass of left kid...

The translocation t(11;22) is a common chromosomal abnormality detected both in Ewing’s sarcoma and in primitive neuroectodermal tumor cells. The translocation results in an EWS-Fli1 fusion gene, made up of the 5 9 half of the EWS gene on chromosome 22 fused to the 3 9 half of the Fli1 gene on chromosome 11. Recent studies have evaluated possible roles of the fusion gene products. However, the ...

Introduction: Ewing sarcoma family of tumors (ESFT) are a group of small round cell tumors showing varying degrees of neuroectodermal differentiation with Ewing sarcoma being the least differentiated. Primitive neuroectodermal tumors (PNET) show neuroectodermal differentiation by light microscopy, immune histochemistry (IHC) or electron microscopy [1]. According to WHO classification of bone an...

RATIONALE Central nervous system primitive neuroectodermal tumors (CNS PNETs) mostly occur in children and present as cerebellar medulloblastoma. A few cases of PNETs occur in the cerebral hemisphere. The presence of a PNET in ventricles is extremely rare. The prognosis of CNS PNET is extremely poor, and the 5-year survival rate does not exceed 35%. In the present study, we describe the first c...

Extraosseous Ewing’s sarcoma/primitive neuroectodermal tumor is a rare malignant tumor with poor outcome. It is mostly reported in the second decade of life with equal in males and females. It is an aggressive tumor with unavoidable multiple recurrences and relatively poor prognosis. These tumors can be easily misdiagnosed for different tumors due to lack of established diagnostic pathological ...

2. Zanetti G, Nobre LF, Mançano AD, et al. Nodular reversed halo sign caused by pulmonary tuberculosis, confirmed by sputum culture. Radiol Bras. 2013;46(6):ix–x. 3. Amoedo MK, Souza LVS, Souza AS, et al. Pulmonary interstitial emphysema: a case report and review of the literature. Radiol Bras. 2013;46: 317–9. 4. Koenigkam Santos M, Barreto ARF, Chagas Neto FA, et al. Neuroendocrine tumors of t...

•Primitive neuroectodermal tumor of the uterus is extremely rare.•Diagnosis requires timely evaluation with molecular analysis.•Different combinations of adjuvant chemotherapy have been reported.

Ewing sarcoma (ES)/primitive neuroectodermal tumor (PNET) is a malignant small round blue cell neoplasm of presumed neuroectodermal origin that affects bones and soft tissue in children and young adults. Nearly 80% of the patients are younger than 20 years. The tumor cells characteristically express CD99 (MIC2 antigen), a glycoprotein localized on cell membrane. The defining feature of ES/PNET ...