This paper is devoted to probability-statistical analysis of Jackson opened and closed networks. A problem of an estimation of product limit distributions parameters using load coefficients of network nodes is solved. Cooperative effects in aggregated opened and closed networks are investigated and optimization procedures of their limit deterministic characteristics are constructed. Formulas of...

Biologics manufacturing requires the clearance of Host Cell Proteins (HCPs) from recombinant therapeutic protein to acceptable low levels to ensure product purity and patient safety. To ensure adequate removal, a highly sensitive method, commonly in the form of Enzyme-Linked Immunosorbent Assay (ELISA), is necessary to quantify the HCPs amount in process intermediates and drug substance. We rep...