Abstract Introduction Arterial thrombosis is the most common age-associated event underlying major adverse cardiovascular (CV) events. The interplay between vascular endothelium, platelets, and coagulation cascade leads to thrombus formation, which results in cessation of blood supply downstream tissues. Hutchinson-Gilford Progeria Syndrome (HGPS) a rare genetic condition with striking features...

This session was dedicated to patients, their relatives and delegates of Family Associations (the Progeria Family Circle, the European Association of Progeria Families; AIProSaB, the Italian Association for Progeria, Sammy Basso; AIDMED, the Italian Association for Emery-Dreifuss Muscular Dystrophy; the Associazione Alessandra Proietti for Emery-Dreifuss Muscular Dystrophy), with the main objec...

Two Iranian cases with very rare progeroid syndrome are reported. The first is a 24-year-old girl who has been healthy till her 13th birthday. From that time she has been suffering from a progressive generalized and multi-systemic illness. The cardinal clinical findings were growth retardation, subcutaneous fat loss, skin dryness and wrinkling, scattered focal sclerodermoid-like changes, promin...

Progeria is an autosomal recessive disorder showing precocious senility. The cultured skin fibroblast from both the homozygous affected individual and the heterozygous parents can be distinguished from normals by decreased cell growth in culture. Mitotic activity, DNA synthesis, and cloning efficiency are markedly reduced.