Abstract Background and Aims Chronic kidney disease (CKD) can be considered an age-related disorder. Recent studies have shown the involvement of activation cellular senescence mechanisms in aging. Intensive research to develop pharmacological approaches targeting is under investigation. Among novel therapeutic options, epigenetic drugs, such as bromodomain extra terminal BET inhibitors, are be...

moving in line with the postulation that metadiscourse (md) markers help transform a dry and tortuous piece of text into a coherent and reader-friendly one, the researchers in the current study attempted to investigate the effect different metadiscourse markers might have on iranian efl learners’ perception of written texts. to this end, 120 undergraduate english students were given three diffe...

metadiscourse is a widely used term in current discourse analysis and language education, referring to an interesting, and relatively new approach to conceptualizing interaction between text producers and their texts and between text producers and users. despite the growing importance of the term, however, it is often understood in different ways and used to refer to different aspects of langua...

BACKGROUND: Hormonal contraceptive therapy is considered the easiest and most convenient method. Commercially, available combination differs in their composition concentration of combined constituents. These variations make some these products preferred over others by consumers based on side effects profile. AIM: The objective current research was to ascertain proinflammatory influences commerc...

We aim to explore the influence of Guizhi decoction(GD) on inflammatory response in myocardial ischemia models. 45 New Zealand rabbits were divided into three groups randomly: sham control group, group and + decoction treatment group. The treated with or saline for 20 days. After that, model was created by left anterior descending coronary artery ligation. Color Doppler Echocardiography compute...

Studies on sensitive skin pathophysiology in infants are challenging because most assessment methods require self-reporting of signs. In this study, we aimed to identify and characterize children for the first time. A newly developed parent-reported questionnaire was used recruit with skin. This also tested an adult group. Hydration, transepidermal water loss (TEWL), inflammatory markers (cytok...

Rationale: Angiotensin-converting enzyme (ACE)2 opposes the actions of angiotensin (Ang) II by degrading it to Ang 1-7. Objective: Given the important role of Ang II/Ang 1-7 in atherogenesis, we investigated the impact of ACE2 deficiency on the development of atherosclerosis. Methods and Results: C57Bl6, Ace2 knockout (KO), apolipoprotein E (ApoE) KO and ApoE/Ace2 double KO mice were followed u...

It has previously been reported that hypertension induced by the chronic blockade of NO production is characterized by a proinflammatory phenotype of the arterial wall associated with a periarterial accumulation of inflammatory cells. In the present study, the cellular and molecular mechanisms involved in the luminal and perivascular accumulation of inflammatory cells were evaluated in the aort...

Multiple myeloma (MM) is a malignant plasma cell disease. Several proinflammatory cytokines produced by malignant plasma cells and bone marrow (BM) stromal cells are involved in the pathogenesis of the disease. We evaluated serum levels of the proinflammatory cytokines Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), macrophage inflammatory protein-1α (MIP-1α), in MM patients...

BACKGROUND Recent clinical studies have suggested a major protective role for the antioxidant enzyme glutathione peroxidase-1 (GPx1) in diabetes-associated atherosclerosis. We induced diabetes in mice deficient for both GPx1 and apolipoprotein E (ApoE) to determine whether this is merely an association or whether GPx1 has a direct effect on diabetes-associated atherosclerosis. METHODS AND RES...