Nuclear power holds the promise of a sustainable, affordable, carbon-friendly source of energy for the twenty-first century on a scale that can help meet the world's growing need for energy and slow the pace of global climate change. However, a global expansion of nuclear power also poses significant challenges. Nuclear power must be economically competitive, safe, and secure; its waste must be...

Background: Dental Pulp Stem Cells (DPSCs) are multipotent mesenchymal stem cells. DPSCs can renew themselves and differentiate into various cell types such as adipocytes, osteocytes, neurons, etc. DPSCs possess immunomodulatory properties and can inhibit peripheral blood mononuclear cell (PBMC) proliferation. Recent studies showed that conditioned-medium mesenchymal stem cells also had immunos...

The strong contribution of RAS-related protein 1b (Rap1b) to cytoskeleton remodeling determines intracellular and extracellular physiological activities, including the successful infection viruses in permissive cells, but its role HSV-1 life cycle is still unclear. Here, we demonstrated that immediate early (IE) gene ICP4 inhibits kinase A (PKA) phosphorylation induce Rap1b-activation-mediated ...

BACKGROUND The rapid expansion of direct-to-consumer wearable fitness products (eg, Flex 2, Fitbit) and research-grade sensors (eg, SenseCam, Microsoft Research; activPAL, PAL Technologies) coincides with new opportunities for biomedical and behavioral researchers. Underserved communities report among the highest rates of chronic disease and could benefit from mobile technologies designed to fa...

Chronic myelogenous leukemia (CML) evolves from a chronic phase characterized by the Philadelphia chromosome as the sole genetic abnormality into blast crisis, which is often associated with additional chromosomal and molecular secondary changes. Although the pathogenic effects of most CML blast crisis secondary changes are still poorly understood, ample evidence suggests that the phenotype of ...

Chronic myelogenous leukemia (CML) evolves from a chronic phase characterized by the Philadelphia chromosome as the sole genetic abnormality into blast crisis, which is often associated with additional chromosomal and molecular secondary changes. Although the pathogenic effects of most CML blast crisis secondary changes are still poorly understood, ample evidence suggests that the phenotype of ...

The frequent and conventional use of non{literal language has been a major stumbling block for natural language processing systems since the early machine translation e orts. Metaphor, metonymy and indirect speech acts are among the most troublesome phenomena. Recent computational e orts addressing these problems have taken an approach that emphasizes the use of systematic knowledge about non{l...