BACKGROUND/AIMS Different drug combinations are used for sedation in colonoscopy procedures. A ketamine-propofol (ketofol) mixture provides effective sedation and has minimal adverse effects. Alfentanil also provides anesthesia for short surgical procedures by incremental injection as an adjunct. However, no study has investigated the use of ketofol compared with an opioid-propofol combination ...

BACKGROUND To define the pharmacokinetic profile of propofol 5% microemulsion formulation in horses. METHODS First, propofol was administered as bolus injection (2 mg kg(-1)) to six xylazine-sedated horses. Secondly, after sedation and bolus injection, propofol was maintained with continuous infusion for 3 h [8.1 (sd 3.2) mg kg(-1) h(-1)] to the same six horses. Thirdly, in two horses, a comm...

background: propofol is a widely used intravenous anesthetic drug. one of its side effects is pain during injection. we investigate the effects of intravenous ondansetron, lidocaine, and their combination on pain reduction of intravenous propofol. methods: eighty eight women with asa class (american society of anesthesiologists) classification i-ii patients undergoing elective gynecologic surge...

conclusions propofol and alfentanil combination can be considered as a treatment approach in the attack phase of cluster headache. introduction cluster headache is a severe hemifacial pain with concomitant symptoms such as lacrimation, conjunctival congestion, and nasal discharge. peripheral (to be a spectrum of trigeminal autonomic cephalgia) and central (hypothalamus) disorders have been sugg...

background: the use of intravenous sedatives is common in gastrointestinal endoscopy. this study is to evaluate the safety and ef_cacy of propofol and/or midazolam in induction of proper sedation in esophagogastroduodenoscopy (egd) compared with a control group, which does not receive sedation for egd. â  methods: four groups (a, b, c and d) of 30 patients each for whom egd had been indicated w...

BACKGROUND It has repeatedly been shown that female patients wake up faster from propofol anaesthesia than male patients. The reason for this is not clear. It is possible that female patients have a more rapid decline in plasma propofol concentration after termination of an infusion, or there could be gender differences in the sensitivity to propofol, making women wake up at higher concentratio...

BACKGROUND The anti-cancer activities of intravenous anesthetic drug propofol have been demonstrated in various types of cancers but not in chronic myeloid leukemia (CML). METHODS We systematically examined the effect of propofol and its combination with BCR-ABL tyrosine kinase inhibitors (TKIs) in CML cell lines, patient progenitor cells and mouse xenograft model. We analyzed propofol's unde...

BACKGROUND The pain on propofol injection is considered to be a common and difficult to eliminate problem in children. In this study, we aimed to compare the efficacy of pretreatment with tramadol 1 mg.kg(-1)and propofol-lidocaine 20 mg mixture for prevention of propofol induced pain in children. METHODS One hundred and twenty ASA I-II patients undergoing orthopedic and otolaryngological surg...

OBJECTIVES Diagnostic gynaecological laparoscopy (DGL) is a brief procedure, generally performed on an outpatient basis. Propofol-fentanyl is often used for anaesthesia in minor outpatient procedures because of its rapid onset, short duration of action and smooth patient awakening. However, propofol has various cardiovascular effects such as reduced arterial pressure, cardiac output and cardiac...