In posterior rhinomanometry (PRM), oropharyngeal pressure is measured using a tube placed between the tongue and the hard palate. For valid results the patient must position the tongue and soft palate so that both the oropharynx and nasopharynx remain open. A high rate of failure of conventional PRM has been reported in normal individuals. In patients with obstructive sleep apnoea syndrome (OSA...

Running title: MRI biomarker for therapy-induced response in gliomas. Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Imaging biomarkers capable of providing early cancer treatment response assessment would allow the opportunity to individualize patient care. For this purpose, images can be obtained which detect treatment-associated alterati...

BACKGROUND Melatonin is extensively used in the USA in a non-regulated manner for sleep disorders. Prolonged release melatonin (PRM) is licensed in Europe and other countries for the short term treatment of primary insomnia in patients aged 55 years and over. However, a clear definition of the target patient population and well-controlled studies of long-term efficacy and safety are lacking. It...

It is known that progesterone receptor (PR) isoform A (PR-A) and isoform B (PR-B) may mediate different effects of progesterone. The objective of this study was to determine if the functions of PR isoforms also vary in response to different PR modulators (PRM). The effects of 7 synthetic PRM were tested in MDA-MB-231 cells engineered to express PR-A, PR-B, or both PR isoforms. The effects of pr...

To understand the processes involved in the spatial and temporal maturation of testicular cells in Squalus acanthias, we used standard morphometry, proliferating-cell nuclear antigen (PCNA) and terminal deoxynucleotidyl transferase-mediated dUTP nick end-labelling (TUNEL) immunohistochemistry. Except for immature spermatocysts (germinal zone, GZ; early-stage pre-meiotic, E-PrM), the number of c...

We fit a Cox proportional hazards (PH) model to interval-censored survival data by first subdividing each individual's failure interval into nonoverlapping sub-intervals. Using the set of all endpoints in set, those that fall are then used as cut points for Each sub-interval has an accompanying weight calculated from parametric Weibull based on current parameter estimates. A weighted PH is with...

Chondroitin sulfate proteoglycans (CSPGs), which are enriched in demyelinating plaques in neurodegenerative diseases, such as multiple sclerosis (MS), impair remyelination by inhibiting the migration and differentiation of oligodendrocyte precursor cells (OPCs) in the central nervous system (CNS). We herein show that protamine (PRM, also known as a heparin antagonist) effectively neutralizes th...

Why is probabilistic roadmap (PRM) planning probabilistic? How does the probability measure used for sampling a robot’s configuration space affect the performance of a PRM planner? These questions have received little attention so far. This paper tries to fill this gap, with the intent to identify promising directions to improve future planners. It introduces the probabilistic foundations of PR...

M. Ernest J. M. Nisavic The current stage of information technology (IT) evolution focuses on moving from a technology-based to a services-based orientation. To that end, IT leadership has had to shift from focusing primarily on technological issues to learning to manage IT like a business, with IT services as the primary ‘‘product’’ produced and consumed by customers. The Component Business Mo...