نتایج جستجو برای: prostaglandin e2 receptors
تعداد نتایج: 262659 فیلتر نتایج به سال:
UNLABELLED Development of potential cancer chemopreventive drugs involves the systematic evaluation of these drugs in preliminary Phase I and II studies in human beings to identify the optimal drug dose, drug toxicity, and surrogate end point biomarker modulation. OBJECTIVES We tested the hypothesis that aspirin, at a single, once-daily 81-mg dose, will reduce colonic mucosal concentration of...
Introduction: Most of the blood vessels are surrounded by perivascular adipose tissue (PVAT) which could regulate vascular functions. Prostaglandin E2 (PGE2) released by PVAT could regulate vascular tone depending on which PGE2 receptors (EP) are expressed by the vessel (vasocontriction via EP1 / EP3, vasodilatation via EP2 / EP4 receptors). During vascular pathologies associated with inflammat...
Background Successful transplantation of haematopoetic stem cells (HSC) is often limited by low transplantation efficiency. This may be enhanced by pharmacological means. In fact, HSCs require a Gas-transduced signal to re-populate the bone marrow [1]. Pretreatment with prostaglandin E2 (PGE2) enhances engraftment via activation of Gascoupled EP2 and EP4 receptors [2]. Treprostinil is a stable ...
Microglia control excitatory synapses, but their role in inhibitory neurotransmission has been less well characterized. Herein, we show that microglia control the strength of glycinergic but not GABAergic synapses via modulation of the diffusion dynamics and synaptic trapping of glycine (GlyR) but not GABAA receptors. We further demonstrate that microglia regulate the activity-dependent plastic...
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