Prostate cancer is one of the most common cancers among men worldwide and in the USA. Most prostate cancer progression either locally invades to seminal vesicles or metastasizes distally to bone. Skin is not a common site of metastasis for the majority of malignancies including prostate cancer. This paper reports two extremely rare cases of prostate carcinoma metastatic to the skin: a 74-year-o...

BACKGROUND The objective of this study was to elucidate the prophylactic effects of 5-alpha reductase inhibitor (e.g., finasteride) and a pure antiandrogen (e.g., casodex) on rat prostate carcinogenesis and to determine whether latent prostate carcinoma can be prevented to develop to clinically significant cancer by use of these drugs. METHODS F344 rats were subcutaneously administered 3,2'-d...

BACKGROUND Prostate carcinoma is among the most common solid tumors to secondarily involve the male breast. Prostate specific antigen (PSA) and prostate-specific acid phosphatase (PSAP) are expressed in benign and malignant prostatic tissue, and immunohistochemical staining for these markers is often used to confirm the prostatic origin of metastatic carcinoma. PSA expression has been reported ...

Aurora kinase B, playing a vital, important role in mitosis, is frequently detected to be overexpressed in many cancer cell lines and various tumor tissues, including prostatic carcinoma. Given the essential function of Aurora kinase B in mitosis and its association with tumorigenesis, it might be a drug target for prostatic carcinoma treatment. In our study, short hairpin RNA targeting Aurora ...

Urinoma formation as the first manifestation of carcinoma prostate is uncommon and has been reported only twice in literature. We report a case prostatic an elderly man who presented emergency department with left-sided abdominal pain. His radiological investigations revealed urinoma dilatation entire ureter enlarged areas varied intensity especially peripheral zone left lobe. In view raised se...

Background: To correct patient positioning errors (setup errors) during prostate cancer treatment using EPID and fiducial gold markers, to improve the accuracy of the dose delivery in these patients. Materials and Methods: Fifteen patients with localized prostate carcinoma after implantation of fiducial gold markers in their prostate gland underwent the five-field IMRT planning technique. The p...

Alterations of the Wnt/beta-catenin signaling pathway are positively associated with the development and progression of human cancer, including carcinoma of the prostate. To determine the role of activated Wnt/beta-catenin signaling in mouse prostate carcinogenesis, we created a mouse prostate tumor model using probasin-Cre-mediated deletion of Apc. Prostate tumors induced by the deletion of Ap...

Metastasis of prostate carcinoma to the testis is seldom reported. The tumour may spread from the prostatic urethra by retrograde venous extension, arterial embolism or through direct invasion into the lymphatics and lumen of the vas deferens. Clinical manifestations of secondary testicular tumours from the prostate are most often unsuspected clinically and are instead detected incidentally dur...

background: to correct patient positioning errors (setup errors) during prostate cancer treatment using epid and fiducial gold markers, to improve the accuracy of the dose delivery in these patients. materials and methods: fifteen patients with localized prostate carcinoma after implantation of fiducial gold markers in their prostate gland underwent the five-field imrt planning technique. the p...

BACKGROUND It has been hypothesized that high androgen levels are determinants of prostate carcinoma. METHODS Serum concentrations of testosterone, sex hormone-binding globulin (SHBG), and androstenedione were analyzed to determine their role as predictors of prostate carcinoma in a longitudinal, population-based, nested case-control study. The serum concentrations of testosterone, SHBG, and ...