Calf thymus histories comprising two fractions, one rich in lysine, the other having roughly equal amounts of lysine and arginine, Loligo testes histones rich in arginine, and salmine, are compared with respect to their amino acid compositions, and their staining properties when the proteins are fixed on filter paper. The three types of basic proteins; somatic, arginine-rich spermatid histones,...

BACKGROUND Protamine content is necessary for proper sperm chromatin condensation and subsequent male fertility. The exact effect of smoking on male fertility remains controversial. The objective of this study was to evaluate the effect of smoking on protamine content of sperm in smoker and non-smoker patients. METHODS Protamines 1 (P1) and 2 (P2) were quantified by gel electrophoresis in the...

Little is known about the genetic basis of evolutionary changes in sperm phenotype. Postcopulatory sexual selection is associated with differences in protamine gene sequences and promoters and is a powerful force acting on sperm form and function, although links between protamine evolution and sperm phenotype are scarce. Protamines are involved in sperm chromatin condensation, and protamine def...

The inactivation of thrombin by serum follows a first order kinetics with thrombin concentrations of the order of 20 to 40 units per ml. of serum. With higher thrombin concentrations of 300 to 600 units per ml. of serum, the rate slows down and not the logarithm of the clotting time, but the clotting time itself increases proportionally with the incubation time. The antithrombic factor is stabl...

freely soluble and hence was rapidly absorbed. Its effect was rapidly felt and almost as rapidly exhausted. Hence there were frequent hypoglycemic reactions which alarmed the patients and sometimes led to their refusing to continue a treatment which appeared to be and was in fact dangerous. In order to avoid sudden falls in blood-sugar various attempts have been made to prolong the action of in...

Heparin was discovered 90 years ago,1 and within 2 decades it was being widely used as an anticoagulant.2 The numerous advantages of heparin lend to its broad use including its immediate onset of action, relatively short half-life ( 60 minutes), simple laboratory monitoring (aPTT), ability to be reversed (using protamine), and low cost. Despite a long experience of using heparin, the counterint...