Nonselective cell damage remains a significant limitation of radiation therapies in cancer. Decades successful integration with other medicinal chemistry strategies significantly improved therapeutic benefits Advancing such technologies also led to the development specific photopharmcology-based approaches that cancer selectivity and provided researchers spatiotemporal control over degradation ...

OBJECTIVE A decrease in muscle protein turnover and therefore in muscle mass is a hallmark of aging. Because the circulating levels of the bone-derived hormone osteocalcin decline steeply during aging in mice, monkeys and humans we asked here whether this hormone might regulate muscle mass as mice age. METHODS We examined muscle mass and strength in mice lacking osteocalcin (Ocn-/-) or its re...

this study was carried out to determine the effects of gamma irradiation on dry matter (dm) and on crude protein (cp) degradation of rapeseed meal, using nylon bags and sds-page techniques. ruminal nylon bags of either untreated or irradiated rapeseed meal at doses of 25, 50 and 75 kgy were suspended in the rumen of four non-lactating holstein cows for up to 48 h. intestinal crude protein diges...

Regulated protein degradation is crucial for virtually every cellular function. Much of what is known about the molecular mechanisms and genetic requirements for eukaryotic protein degradation was initially established in Saccharomyces cerevisiae. Classical analyses of protein degradation have relied on biochemical pulse-chase and cycloheximide-chase methodologies. While these techniques provid...