Abstract Ethanol has a vast consumption around the world. Many researches confirmed some adverse effect of this component on human health. In addition, recent studies showed significant alteration in both cellular population, and protein profile of human foreskin fibroblast cell line (HFFF2) in the specific dosage of ethanol. Here, the role and interaction of some proteins (characterized by sig...

MOTIVATION Prediction of protein folding patterns is one level deeper than that of protein structural classes, and hence is much more complicated and difficult. To deal with such a challenging problem, the ensemble classifier was introduced. It was formed by a set of basic classifiers, with each trained in different parameter systems, such as predicted secondary structure, hydrophobicity, van d...

In this paper we study the potential of simple linear gene-protein interaction networks to store sparse input-output patterns. This problem bears similarity to the engineering task of reconstructing gene networks from time series of expression data, such as sets of microarrays. This is currently an intensively studied field where some results are directly applicable to our context. The central ...

In this paper we study the potential of simple linear gene-protein interaction networks to store sparse input-output patterns. This problem bears similarity to the engineering task of reconstructing gene networks from time series of expression data, such as sets of microarrays. This is currently an intensively studied field where some results are directly applicable to our context. The central ...

Paper electrophoresis for studying the serum protein pattern is of particular value in infancy because of the small volume of blood required. Despite improved methods of diagnosis and increased knowledge of the aetiology of wasting disorders in infancy, some cases of failure to thrive still present diagnostic difficulties. Cases in which diarrhoea, respiratory infection and wasting are associat...

were determined in the cord blood of 75 African and 10 European babies born in Zambia, and in the venous blood of 5 pregnant African women at term. When the high y-globulin fraction was excluded, there was no significant difference between the pattern of serum proteins of the Africans and the Europeans at birth. Present evidence favours the view that the high serum y-globulin and low albumin of...

sequence-to-model alignments. Although DSMs are generally represented as hidden Markov models (HMMs), they are designed around a set of rules rather than trained on a large representative set, as most HMMs are. The DSM approach to protein structure modeling has many advantages: flexibility, generality, a high degree of abstraction, and the possibility to build models for hypothetical structures...

We are carrying out research into developing several approaches to pattern discovery in protein topology diagrams, and comparing them. The underlying motivation is to eeciently automatically generate patterns classifying sets of proteins and to apply this to characterising databases of protein structure. We are using TOPS protein topology diagrams, which we have formalised as a restricted kind ...

Proteomic profiles of myocardial tissue in two different etiologies of heart failure were investigated using high performance liquid chromatography (HPLC)/Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Right atrial appendages from 10 patients with hemodynamically significant isolated aortic valve disease and from 10 patients with isolated symptomatic coronary heart dis...