Medicinal plants are valuable and used for the synthesis of numerous drugs. Indigenous plants are traditionally used against various ailments. Present work is based on the research conducted on methanolic crude plant extracts of three medicinal plants of family solanaceae i.e. leaves of Datura inoxia Mill., Withania somnifera (L.) Dunal and Solanum surrattense were screened to investigate the b...

As a part of our research programme of investigating some medicinal plants cultivated in Beni-Suef Governorate (Egypt) as anticancer agents. Bioassay-guided fractionation study using brine shrimp lethality and Ehrlich Ascites carcinoma assays revealed that the PE extract (PE) of Withania somnifera (L.) Dunal leaves retained most cytotoxic activity among other extracts. The total phenolics, flav...

Parkinson's disease remains as one of the most common debilitating neurodegenerative disorders. With the hopes of finding agents that can cure or reduce the pace of progression of the disease, we studied two traditional medicinal plants: Centella asiatica and Withania somnifera that have been explored in some recent studies. In agreement with the previous work on ethanol extracts of these two p...

The present study on effect of imidacloprid induced oxidative stress and its amelioration was carried out at definite time periods in different groups for 90 days on 48 layer birds of above 2 months age that were divided into six groups consisting of 8 in each. The birds were divided into group 1 was control, group 2 was treated with imidacloprid @ 200 ppm in feed, group 3 was treated with vita...

An elderly woman presented with acne and male pattern alopecia, which upon diagnostic evaluation was found to be due to nonclassic 11-hydroxylase deficiency. We previously reported that Ashwagandha root ameliorates nonclassic 3-β-ol dehydrogenase and aldosterone synthase deficiencies. This is the first report of its use being associated with amelioration of nonclassic 11-hydroxylase deficiency,...

Withania somnifera (L.) Dunal, a highly reputed medicinal plant, synthesizes a large array of steroidal lactone triterpenoids called withanolides. Although its chemical profile and pharmacological activities have been studied extensively during the last two decades, limited attempts have been made to decipher the biosynthetic route and identification of key regulatory genes involved in withanol...

“Withanolides”, the legendary bioactive metabolite present in leaves and roots of Withania somnifera, is well known for its therapeutic activities since ancient times. Several efforts have been made to produce these metabolites under in vitro condition. In the present study, we have tested the effects of exogenous supplementation of IBA and IAA in W. somnifera in vitro root cultures with the ai...