The increasing amount of available high-content data in genomics, proteomics, and metabolomics has significantly improved the predictive power model accuracy genome-scale metabolic network models recent years. We review constraint-based modeling approaches that incorporate genomics proteomics to form resource allocation models. Different build related enzyme-constrained are discussed evaluated ...

This unit describes strategies for studying the proteomes of organelles, which is one example of targeted proteomics. It relies heavily on previously published units dealing with organelle preparation, protein solubilization, and proteomics techniques. A specific commentary for organelle proteomics is provided. Specific protocols for the isolation of nuclei from various sources (cell cultures, ...

Objective(s): Schwann cells (SCs) have a wide range of applications as seed cells in the treatment of nerve injury during transplantation. However, there has been no report yet on kinds of proteomics changes that occur in Schwann cells before and after peripheral nerve injury.Materials and Methods: Activated Schwann cells (ASCs) and normal Schwann cells (NSCs) were obtained from adult Wistar ra...

Traditional proteomics analysis is plagued by the use of arbitrary thresholds resulting in large loss of information. We propose here a novel method in proteomics that utilizes all detected proteins. We demonstrate its efficacy in a proteomics screen of 5 and 7 liver cancer patients in the moderate and late stage, respectively. Utilizing biological complexes as a cluster vector, and augmenting ...

Clinical Proteomics is an emerging interdisciplinary research field that coalesces researchers from many different areas of biomedical research into one of the most likely disciplines to successfully foster the translation of basic scientific knowledge into clinical applications for the benefit of the patient. Major research interests that are expected to profit from the application of proteomi...

PROTEOMICSVolume 23, Issue 5 2370033 CONTENTSFree Access Contents: Proteomics 5'23 First published: 01 March 2023 https://doi.org/10.1002/pmic.202370033AboutRelatedInformationPDFPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessClose modalShare full-text accessPlease review our Terms and Conditions of Use check box below share v...

Proteomics is critical to identify the properties and functions of proteins involved in the mechanism regulating the male reproductive tract function. This approach is important in male fertility assessment and clinical diagnosis of the physiological state of individual reproductive organs. Proteomics also provides a tool to understand the interactions of seminal plasma proteins with spermatozo...