‎In this paper‎, ‎we define and study the notion of zero elements in topoframes; a topoframe is a pair‎ ‎$(L‎, ‎tau)$‎, ‎abbreviated $L_{ tau}$‎, ‎consisting of a frame $L$ and a‎ ‎subframe $ tau $ all of whose elements are complemented elements in‎ ‎$L$‎. ‎We show that‎ ‎the $f$-ring $ mathcal{R}(L_tau)$‎, ‎the set of $tau$-real continuous functions on $L$‎, ‎is uniformly complete‎. ‎Also‎, ‎t...

In these proceedings, a description of the reconstruction and identification methods for tau leptons in ATLAS at the LHC is presented. Identifying tau leptons is essential in many analyses, be it for Standard Model (SM) and Higgs boson signatures or searches for physics beyond the SM. The decay of the tau particle with leptonic as well as hadronic decay modes and its short lifetime makes it esp...

Stressful life experiences are likely etiological factors in sporadic forms of Alzheimer's disease (AD). Many AD patients hypersecrete glucocorticoids (GCs), and their GC levels correlate with the rate of cognitive impairment and extent of neuronal atrophy. Severity of cognitive deficits in AD correlates strongly with levels of hyperphosphorylated forms of the cytoskeletal protein TAU, an essen...

BACKGROUND The misfolding of amyloidogenic proteins including human Tau protein, human prion protein, and human α-synuclein is involved in neurodegenerative diseases such as Alzheimer disease, prion disease, and Parkinson disease. Although a lot of research on such amyloidogenic proteins has been done, we do not know the determinants that drive these proteins to form fibrils and thereby induce ...

Abnormally phosphorylated Tau protein, the major component of neurofibrillary tangles, is critical in the pathogenesis of Alzheimer's disease and related Tauopathies. We used Drosophila to examine the role of key disease-associated phosphorylation sites on Tau-mediated neurotoxicity. We present evidence that the late-appearing phosphorylation on Ser(238) rather than hyperphosphorylation per se ...

The multisubunit yeast transcription factor IIIC (TFIIIC; also called tau) can undergo considerable conformational changes upon binding to the A and B blocks of tRNA genes. After binding to DNA encoding tRNA (tDNA), TFIIIC acts as an assembly factor to recruit an initiation factor, TFIIIB, via its tau 131 subunit. We have cloned the gene encoding the tau 131 subunit and named it TFC4. This gene...

Activity-dependent neuroprotective protein (ADNP) is deregulated in Alzheimer's disease (AD) and in schizophrenia and mutated in autism. In mice, ADNP is essential for brain formation and ADNP haploinsufficiency is associated with cognitive and social deficits and tauopathy. Tauopathy, a major pathology in AD, is also found in ~45% of frontotemporal dementias (FTDs). Tau transcript, a product o...

Alzheimer's disease (AD) is the most common cause of dementia worldwide. One of the main pathological changes that occurs in AD is the intracellular accumulation of hyperphosphorylated Tau protein in neurons. Cyclin-dependent kinase 5 (CDK5) is one of the major kinases involved in Tau phosphorylation, directly phosphorylating various residues and simultaneously regulating various substrates suc...

Metrized graphs are finite graphs equipped with a distance function on their edges. For a metrized graph Γ, the tau constant τ(Γ) is an invariant which plays important roles in both harmonic analysis on metrized graphs and arithmetic of curves. T. Chinburg and R. Rumely [CR] introduced a canonical measure μcan of total mass 1 on a metrized graph Γ. The diagonal values of the Arakelov-Green’s fu...

The microtubule associated protein tau is essential for the development and maintenance of the nervous system. Tau dysfunction is associated with a class of diseases called tauopathies, in which tau is found in an aggregated form. This paper focuses on a small aggregating fragment of tau, (273)GKVQIINKKLDL(284), encompassing the (PHF6*) region that plays a central role in tau aggregation. Using...