نتایج جستجو برای: pseudohypoaldosteronism type 1
تعداد نتایج: 3647227 فیلتر نتایج به سال:
Mendelian forms of hypertension have ushered in a revolution in our knowledge of blood pressure and volume regulation. If we include information on syndromes involving low blood pressure, this knowledge base is doubled. Glucocorticoid remediable aldosteronism, apparent mineralocorticoid excess, and mutations in the mineralocorticoid receptor gene have given us brilliant insights into mineraloco...
The epithelial sodium channel (ENaC), a heterotrimeric complex composed of alpha, beta, and gamma subunits, belongs to the ENaC/degenerin family of ion channels and forms the principal route for apical Na(+) entry in many reabsorbing epithelia. Although high affinity ENaC blockers, including amiloride and derivatives, have been described, potent and specific small molecule ENaC activators have ...
Discrete sine-Gordon (SG) chains are studied with path-integral molecular dynamics. Chains commensurate with the substrate show the transition from pinning to quantum creep at bead masses slightly larger than in the continuous SG model. Within the creep regime, a field-driven transition from creep to complete depinning is identified. The effects of disorder on the chain's dynamics depend on the...
- pseudohypoaldosteronism (p'ha) is referred to a state of endorgan unresponsiveness to aldosterone. in this article a 12 day - old mule newborn is presented with hyponatremia, hyperkalemia and metabolic acidosis. aldosterone level and plasma renin activity were high. mineralocorticoids had no therapeutic effect, hut normal saline infusion improved electrolyte imbalance. salt-rich diet was succ...
Deletion of exon 9 from Cullin-3 (CUL3, residues 403-459: CUL3(Δ403-459)) causes pseudohypoaldosteronism type IIE (PHA2E), a severe form of familial hyperkalaemia and hypertension (FHHt). CUL3 binds the RING protein RBX1 and various substrate adaptors to form Cullin-RING-ubiquitin-ligase complexes. Bound to KLHL3, CUL3-RBX1 ubiquitylates WNK kinases, promoting their ubiquitin-mediated proteasom...
Spatiotemporal chaos arising from the competition between sine-Gordonbreather and kink-antikink-pair solitons by reshaping an ac force is demonstrated. After introducing soliton collective coordinates, Melnikov’s method is applied to the resulting effective equation of motion to estimate the parameterspace regions of the ac force where homoclinic bifurcations are induced. The analysis reveals t...
Coherent optical OFDM (CO-OFDM) has recently been proposed and the proof-of-concept transmission experiments have shown its extreme robustness against chromatic dispersion and polarization mode dispersion. In this paper, we first review the theoretical fundamentals for CO-OFDM and its channel model in a 2x2 MIMO-OFDM representation. We then present various design choices for CO-OFDM systems and...
In our article, ‘‘The Continuation of Intimate Partner Violence from Adolescence to Young Adulthood’’ (Cui, Ueno, Gordon, & Fincham, 2013), we found that being victimized by relationship partners in adolescence was significantly associated with both perpetration and victimization in romantic relationships in young adulthood. Though not our primary focus, we included gender as a covariate and te...
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