Purpose We report a case of corneal endothelial graft failure secondary to dexamethasone intravitreal implant (Ozurdex™) migration into the anterior chamber (AC). Observations A 53-year-old man with a history of bilateral idiopathic chronic uveitis, had a right anterior vitrectomy and AC intraocular lens (ACIOL) with a peripheral iridotomy. He received an intravitreal Ozurdex™ implant for rig...

PURPOSE The human cornea, a tissue much exposed to oxidative stress, is rich in extracellular superoxide dismutase (SOD). In this study, the contents and distributions of the SOD isoenzymes in the normal human cornea were compared with those in corneas affected by keratoconus and bullous keratopathy. METHODS The central and peripheral parts of normal human corneas were analyzed separately. Ce...

AIMS To investigate the ultrastructural localisation of proteoglycans (PG), betaig-h3 (keratoepithelin), tenascin-C (TN-C)), fibrillin, and fibronectin in bullous keratopathy (BK) corneas. METHODS Five corneas from cases of pseudophakic bullous keratopathy (BK) were examined by electron microscopy. PG were demonstrated using cuprolinic blue, and the proteins betaig-h3, TN-C, fibrillin, and fi...

OBJECTIVE To evaluate long-term anatomical and functional outcomes of a modified osteo-odonto-keratoprosthesis (OOKP) technique for treatment of corneal blindness from various etiologies. METHODS Two-hundred three patients (224 eyes) underwent modified OOKP surgery between 1973 and 1999. Of the original cohort, 181 patients (98 men and 83 women; mean [SD], age 54.3 [15] years) in whom a stand...

PURPOSE To report the outcome of Descemet stripping automated endothelial keratoplasty (DSAEK) for bullous keratopathy after Sato anterior-posterior radial keratotomy (APRK). METHODS The clinical records of patients who had DSAEK surgery for bullous keratopathy after APRK were reviewed. RESULTS Five eyes of 4 patients (4 men) were included. The mean age at DSAEK surgery was 81.8 ± 7.1 years...

Subepithelial fibrosis (SEF) and the transdifferentiation of keratocytes into fibroblasts or myofibroblasts (Fbs/MFbs) have been detected in the cornea of individuals with bullous keratopathy. We examined the anterior cornea of bullous keratopathy patients for such changes after Descemet's stripping automated endothelial keratoplasty (DSAEK). Twenty-two individuals who underwent unilateral DSAE...

purpose: to describe a new noninvasive method to assure correct orientation of donor lenticules in descemet stripping automated endothelial keratoplasty (dsaek) surgery. methods: dsaek surgery was performed in three eyes with the diagnosis of pseudophakic bullous keratopathy (pbk). for the laboratory part of the study, two whole globes and two precut corneoscleral buttons were used. the donor l...

PURPOSE To establish the effectiveness of amniotic membrane transplantation (AMT) in relieving pain and discomfort in patients with painful bullous keratopathy and its role in improving vision in eyes with visual potential. METHODS Seven eyes of seven consecutive patients with painful corneal conditions were included in a retrospective interventional noncomparative case series performed at Ma...