Allogeneic hematopoietic cell transplantation (HCT) is a well-established therapeutic modality effective for a variety of hematological malignancies but, unfortunately, is associated with significant morbidity and mortality related to cancer relapse as well as to transplant-related complications including graft-versus-host-disease (GvHD). Natural killer (NK) cells are the first donor-derived ly...

Abstract We were the first to demonstrate that targeting JAK1/2 using baricitinib (BARI) and ruxolitinib (RUX) prevents treats GVHD while enhancing multi-lineage hematopoietic reconstitution graft-vs-leukemia (GvL) effect in mouse models of allogeneic cell transplantation (allo-HCT). However, unlike BARI, RUX fails completely prevent or treat GvHD. To elucidate mechanism underlying superiority ...

Treatment of acute graft-versus-host disease (GVHD) has evolved from a one-size-fits-all approach to a more nuanced strategy based on predicted outcomes. Lower and time-limited doses of immune suppression for patients predicted to have low-risk GVHD are safe and effective. In more severe GVHD, prolonged exposure to immunosuppressive therapies, failure to achieve tolerance, and inadequate clinic...

GVHD: graft-versus-host-disease INTRODUCTION Acute graft-versus-host disease (GVHD) is the major complication of hematopoietic cell transplantation and affects multiple organs and systems, most commonly the skin. We report a case of acute GVHD localized to a tattoo in a patient with a history of allogeneic hematopoietic cell transplantation and describe typical and atypical cutaneous findings i...

Graft-versus-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation. GVHD is caused by donor T cells that recognize and react to recipient histocompatibility differences, resulting in significant morbidity and mortality. The pathophysiology of GVHD is complex, which occurs in three phases: induction phase, activation phase and effector phase. Numerous studies have...

INTRODUCTION The transplantation of hematopoietic stem cells (HSCT) is a therapeutic intervention where the hematopoietic stem cells and the cells originating from them are being removed and replaced by the normal stem cells of donor or the patient him/her-self. HSCT today represent standardized biological manipulation for treating malignant, genetic and autoimmune diseases. The application of ...

Abstract It has been observed that a constriction of the gut microbiome occurs with high fat diet, and likewise decreased diversity is directly correlated more severe graft-versus-host disease (GvHD) following allogeneic hematopoietic stem cell transplantation. Taken together it plausible not only content, but source dietary could influence microbiota GvHD outcome. We sought to address this que...

Objectives Graft-versus-host disease (GVHD) is an important complication of bone marrow transplantation. Recent reports suggest the significance T-cell subsets (Th1, Th17, and cytotoxic CD8+ T cells) as well CD163+ macrophages in development cutaneous GVHD. produce various chemokines to establish immunological microenvironment following stimulation by stromal factors lesional skin. Thus, purpos...

Eigenvalues of a potential dynamical system with damping forces that are described by an indefinite real symmetric matrix can behave as those of a Hamiltonian system when gain and loss are in a perfect balance. This happens when the indefinitely damped system obeys parity-time ( ) symmetry. How do pure imaginary eigenvalues of a stable -symmetric indefinitely damped system behave when variation...