نتایج جستجو برای: ptch1
تعداد نتایج: 516 فیلتر نتایج به سال:
The understanding of the anatomy and development of fetal and adult hair follicles and the molecular study of the major embryonic pathways that regulate the hair follicle have led to exciting discoveries concerning the development of basal cell carcinoma (BCC). These studies have shed light on the major roles of Sonic hedgehog (Shh) signaling and its interactions with the insulin-like growth fa...
THIRTY-TWO YEARS AGO, Christine Nusslein-Volhard et al. (12) first described the secreted Hedgehog factor (Hh) as a segmentation pattern control gene in Drosophila. Since then, the involvement of the Hedgehog (HH) signaling pathway in development and diseases is undeniable in chordates. Sonic Hedgehog (SHH), Desert Hedgehog, and Indian Hedgehog are the three mammalian orthologs of Drosophila Hh...
Activation of GLI1 which is the transcription factor through Hh signaling mediated has been shown to be a key step in initiation tumorigenic program leading BCC. We recently showed that was also regulated by insulin-like growth 2 mRNA binding protein 1 (IGF2BP1) at post-transcriptional level. IGF2BP1 direct target Wnt/β-catenin critical Wnt-dependent regulation GLI. observed upstream signal IGF...
The hedgehog signaling network regulates pattern formation, proliferation, cell fate and stem/progenitor cell self-renewal in many organs. Altered hedgehog signaling is implicated in 20-25% of all cancers, including breast cancer. We demonstrated previously that heterozygous disruption of the gene encoding the patched-1 (PTCH1) hedgehog receptor, a negative regulator of smoothened (Smo) in the ...
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