BACKGROUND Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease characterized by the presence of one or more lesions on the skin that usually heal spontaneously after a few months. Most cases of CL worldwide occur in Southwest Asia, Africa and South America, and a number of cases have been reported among troops deployed to Afghanistan. No vaccines are available against this disease,...

Leishmania is a protozoan parasite responsible for significant morbidity and mortality worldwide. Few parasites have been subjected to proteomic analysis to date, but a genome sequencing project for Leishmania major is currently underway, making these studies possible. Here we present a high resolution proteome for L. major comprising almost 3700 spots, making it the most complete two-dimension...

While the existence of a molybdenum cofactor common to nitrate reductase, xanthine oxidase, and sulfite oxidase has been finnly established by studies from several laboratories (1-6), the nature of the molecule has not been elucidated. Information available to date has shown that the molybdenum cofactor complex is noncovalently attached to the proteins (2, 4) and is probably a small, dialyzable...

Pteridine-metal complexes have recently been studied to mimic the environment and reactivity of the metal site of the enzymes and some of these have been characterized by X-ray crystallography, however, we have not been able to find any reference to gold(III) complexes with lumazine (pteridine-2,4(1H,3H)dione) ligands. The study of these complexes may be of interest due to the well-established ...

Pteridine derivatives have been shown to interfere with xanthine and guanine metabolism in vitro. 2-Amino-4-hydroxy-6-formylpteridine (l-3) and 2-amino-4-hydroxy-6-hydroxymethylpteridine (3) have been demonstrated to be potent inhibitors of xanthine oxidase in vitro. More recently, it has been observed that crude folic acid (4) and 6-formylpteridine (5) are inhibitors of guanase in vitro. Furth...