Objective This study aimed to evaluate the influence of the NiTi wire in Conventional NiTi (ProTaper Universal PTU) and Controlled Memory NiTi (ProTaper Gold PTG) instrument systems on the quality of root canal preparation. Material and Methods Twelve mandibular molars with separate mesial canals were scanned using a high-definition microcomputed tomography system. The PTU and PTG instruments...

INTRODUCTION The role of brain tissues oxidative damage in learning and memory impairments has been well documented. It is also well known that thyroid hormones have a critical role for the brain functions. The purpose of this study was to investigate the role of brain tissues oxidative damage as a possible mechanism of deleterious effects of propylthiouracil (PTU) - induced hypothyroidism on l...

The objective of this study was to examine the potential radioprotective properties of propylthiouracil (PTU)-induced hypothyroidism against oxidative organ damage induced by irradiation. Sprague-Dawley rats were pre-treated with saline or PTU (10 mg/kg i.p.) for 15 days, and were then exposed to whole-body irradiation (800 cGy). A group of rats were decapitated at 6 h after exposure to irradia...

Study of physiological angiogenesis and associated signalling mechanisms in adult heart has been limited by the lack of a robust animal model. We investigated thyroid hormone-induced sprouting angiogenesis and the underlying mechanism. Hypothyroidism was induced in C57BL/6J mice by feeding with propylthiouracil (PTU). One year of PTU treatment induced heart failure. Both 12 weeks- (young) and 1...

AIMS To determine if thyroid function affects faecal shedding of Escherichia coli O157:H7. METHODS AND RESULTS Eight yearling cattle (n = 4 per treatment group), previously identified as shedding E. coli O157:H7, received either 0 or 10 mg 6-N-propyl-2-thiouracil (PTU) kg(-1) BW day(-1) for 14 days to reduce serum concentrations of the thyroid hormones, T(3) and T(4). Animals were monitored d...

Propylthiouracil (PTU)-induced hypothroidism has been shown to produce a significant increase in the uptake of radiophosphorus (““P) by the testes of young chicks. Continued investigation of this effect demonstrated that thyroidectomy of young birds resulted in elevations in testis 32P uptake comparable to those observed following the administration of PTU. It would thus appear that the increas...

* Correspondence: [email protected] Equal contributors Division of Internal Medicine, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria n°1, 98100 Messina, Italy Figure 1 Immunostaining for α-SMA in cutaneous samples. Representative tissue sample from: (A) Sham animal; (B) HOCl mice; (C) HOCl + PTU animal (original magnification, ×40). The arrows sho...

Persistent cardiovascular pathology has been described in hyperthyroid patients even with effective antithyroid treatment. Here, we studied the effect of a well-known antithyroid drug, propylthiouracil (PTU; 20 mg/kg/day), on thyroxine (T4; 500 µg/kg/day)-induced increase in blood pressure (BP), cardiac hypertrophy, and altered responses of the contractile myocardium both in vivo and ex vivo af...

The antithyroid drugs (ATDs) methimazole (MMI) and propylthiouracil (PTU) have been used for treatment of hyperthyroidism for more than several decades, despite the fact that they are associated with adverse drug reactions that are thought to be autoimmune mediated. We therefore examined histopathologic responses in the immune system in male and female rats given MMI (2, 20 and 200 mg/kg/day, p...

INTRODUCTION New designs and alloys have been developed to increase cyclic fatigue (CF) resistance of rotary files. The aim of this study was to compare CF resistance of ProTaper Universal (PTU; Dentsply Tulsa Dental, Tulsa, OK) and ProTaper Next (PTN, Dentsply Tulsa Dental) instruments at different points of curvature. METHODS A total of 420 files (240 PTU, S1, F1, F2, and F3 and 180 PTN, X1...