Component Based System (CBS) development is integration centric with a focus on selecting components that match stakeholder requirements. Recent research suggests that CBS development needs a quantitative analysis model that evaluates candidate components and facilitates informed decisions during CBS development. To date, there has been little work done on building CBS assessment models that ca...

A recent meta-analysis puts another nail in the coffin of a therapy that held great promise for management of acute respiratory distress syndrome. Two papers further highlight the growing controversy surrounding the safety profile of drotrecogin alpha (activated) and increase the clamour for a new independent trial. Also covered are steroids and their role in preventing postoperative atrial fib...

The authors appreciate Professor Cheng-De Zheng pointing errors in definition of LMI variable [1–8] and would like to correct an error in definition of an LMI variable of the paper [1–8]. In [1–8], Theorems or Corollaries present stability or stabilization criteria for the system with uncertainties or nonlinear perturbations. In [1–8], the LMI variables H in [1–3,5– 8], Hi ði 1⁄4 1;2Þ in [4], a...

Age Determination 105038 Kawano, Y. & Yuhara, M. Chronological and isotope geological study of Cretaceous granitic rocks, upper reach of the Nakagawa river, Fukuoka Prefecture. J. Geol. Soc. Japan, 114, 218-230, 8 figs., 2 tables (in Japanese with English abstract), 2008. Cretaceous granitic rocks, consisting of Itoshima granodiorite and Sawara granite, are occurred at upper reach of the Nakaga...

This study evaluated the use de standards in papers published in Brazilian and international dental journals. Papers published from January 2006 to December 2010 in the following journals were examined: Brazilian Dental Journal (BDJ), Brazilian Oral Research (BOR), Journal of Applied Oral Sciences (JAOS), Journal of Dental Research (JDR) and Dental Materials (DM). In addition to the title and t...

Sepsis is the leading cause of admission to critical care units worldwide, with increasing research and publications reflecting this. Tight control of the blood glucose concentration can reduce morbidity and mortality but the obtained values can be influenced by the method of measurement. Increasing awareness of interactions with patients and relatives can make or break relationships between st...

Studies with negative results rarely hit the headlines. But the results are often just as important as the positive ones. A number of 'negative headline' studies are looked at in this review: intensive insulin therapy regime, thrombolysis in cardiac arrest, the effects of nutritional guidelines and rapid response outreach teams.

Following the success of the activated protein C trial in 2001 [1], interest in anticoagulant therapy for severe sepsis was heightened. A systemic imbalance between procoagulant and anticoagulant pathways exists in severe sepsis, leading to thrombus formation in the microvasculature and to subsequent end-organ injury. Endothelial injury occurring in severe sepsis is thought to be a trigger for ...

Professor Kuroda, Dean, Toho University Professor Takamatsu, Dean, Toho University Professor Igarashi, Director, Tsukuba University Hospital Professor Tanaka, Chairman, Department of Anesthesiology, University of Tsukuba Professor Shintani, Director, JA Toride Medical Center Professor Makita, Chairman, Department of Anesthesiology, JA Toride Medical Center Professor Miyasaka, Director, Tokyo Me...