Autologous blood clot was used to produce pulmonary macroembolism, and lycopodium spores to produce microembolism in nolmal mongrel dogs. Pressures were recorded from the pulmonary artery, left atrium and femoral artery; cardiac output and pulmonary blood volume (PBV) were determined using sequential indicator dilution curves from injections into the pulmonary artery and left atrium. Macroand m...

Autologous blood clot was used to produce pulmonary macroembolism, and lycopodium spores to produce microembolism in nolmal mongrel dogs. Pressures were recorded from the pulmonary artery, left atrium and femoral artery; cardiac output and pulmonary blood volume (PBV) were determined using sequential indicator dilution curves from injections into the pulmonary artery and left atrium. Macroand m...

An 8 year old girl with primary pulmonary hypertension and signs of heart failure was given 17.5 mg of verapamil injected into the pulmonary artery over 25 minutes to test for the reversibility of pulmonary arteriolar obstruction. Pulmonary artery pressure fell from 70/50 to 35/25 mm Hg. Treatment with 40 mg verapamil by mouth four times daily was started, and she was discharged. She gradually ...

Cardiac catheterization is a technique which readily lends itself to the analysis of hemodynamic alterations in the cardio-pulmonary circuit caused by mitral stenosis. The purpose of this report is the evaluation of 50 patients with mitral stenosis by means of this technique, attempting thereby to determine optimal indications for mitral commissurotomy. Of the 50 patients studied, 27 subsequent...

1. Cowie B, Kluger R, Rex S, Missant C. The utility of transoesophageal echocardiography for estimating right ventricular systolic pressure. Anaesthesia 2015; 70: 258–63. 2. Soliman D, Bolliger D, Skarvan K, Kaufmann BA, Lurati Buse G, Seeberger MD. Intra-operative assessment of pulmonary artery pressure by transoesophageal echocardiography. Anaesthesia 2015; 70: 264–71. 3. Skjaerpe T, Hatle L....

Cardiac catheterization of a 79-year-old woman with systemic sclerosis demonstrated severe pulmonary arterial hypertension: a peak systolic pulmonary pressure of 99 mmHg and a mean pulmonary artery pressure of 51 mmHg without an increase in the mean pulmonary capillary wedge pressure. Pulsus alternans was detected in the right ventricle (RV) and pulmonary artery (PA), but not in the pulmonary a...

A 49-year-old woman with primary pulmonary hypertension diagnosed 1 year previously was admitted as part of a research study at Harefield Hospital. She had no known precipitating factors or family history of the disease. Her main symptoms included exertional dyspnea and syncope. Her pulmonary artery systolic pressure was 110 mm Hg, with a mean pulmonary artery pressure of 85 mm Hg. A 24-hour am...

Histamine was administered to dogs by the intravenous route near the right atrium in doses of 9.6 to 19 y/Kg. body weight. It produced a severe drop in systemic blood pressure, negligible changes in heart rate and respiration, usually a fall in cardiac output and no change in left atrial or pulmonary artery wedge pressure. The pulmonary artery pressure showed an initial rise and then a fall fol...

BACKGROUND Pulmonary hypertension is a frequent finding in patients with cardiopulmonary disorders. It is important to recognize pulmonary hypertension due to increased pulmonary vascular resistance (PVR), as this affects treatment and prognosis. Patients with increased PVR have an increased pulmonary pressure reflection. We hypothesized that pressure reflection can be described by echocardiogr...