The differences in efficacy and molecular mechanisms of platinum based anti-cancer drugs cisplatin (CP) and oxaliplatin (OX) have been hypothesized to be in part due to the differential binding affinity of cellular and damage recognition proteins to CP and OX adducts formed on adjacent guanines in genomic DNA. HMGB1a in particular exhibits higher binding affinity to CP-GG adducts, and the exten...

A genetic model-free method for the meta-analysis of genetic association studies is described that estimates the mode of inheritance from the data rather than assuming that it is known. For a bi-allelic polymorphism, with G as risk allele and g as wild-type, the genetic model depends on the ratio of the two log odds ratios, lambda = log OR(Gg)/log OR(GG), where OR(GG) compares GG with gg and OR...

To my parents, with love and gratitude, for believing in me and teaching me to always reach for my dreams. To my beloved dogs Tris and Lizzy, for faithfully accompanying me throughout the long years of my veterinary education.

Abstract This paper deals with some analytic aspects of GG system introduced by I.M. Gelfand and M.I. Graev: we compute the dimension solution space over field meromorphic functions periodic respect to a lattice. We describe monodromy invariant subspace space. provide connection formula between pair bases consisting $\Gamma $-series solutions associated regular triangulations adjacent each othe...