All subjects had clear chest X-rays at entry into the study, and were skin tested with 10 U PPD-B (prepared from Mycobacterium intracellulare) and 3 U of PPD-S (prepared from M. tuberculosis), before being allocated into groups that received placebo, or either high or low doses of Danish or French BCG. The lack of protection overall was documented previously. The new study analyses the results ...

Purified protein derivative (PPD) skin tests often yield poor specificity, so that to develop new serological antigens for distinguishing between Mycobacterium tuberculosis infection and Bacille Calmette-Guerin (BCG) vaccination is a priority, especially for developing countries like China. We predicted the antigenicity for selected open reading frames (ORFs) based on the genome sequences of M....

Eotaxin participation was analyzed during types 1 and 2 lung granuloma formation induced by embolizing Sepharose beads coupled to purified protein derivative (PPD) of Mycobacterium bovis or soluble Ags derived from Schistosoma mansoni eggs. Eotaxin was monitored by protein ELISA and semiquantitative reverse-transcriptase PCR mRNA analysis. Both types 1 and 2 granulomas released eotaxin, but lev...

BACKGROUND Tuberculosis has again emerged as a growing public health concern in the United States. Among the homeless population, increased risk factors contribute to immunodeficiency, which can cause false-negative results on purified protein derivative (tuberculin) (PPD) skin testing, the standard screening procedure for tuberculosis in individuals. We evaluated the accuracy of PPD skin test ...

Despite highly successful eradication efforts in several countries, Mycobacterium bovis infection of cattle remains a significant health concern worldwide. Immune mechanisms of resistance to and/or clearance of M. bovis infection of cattle, however, are unclear. Recent studies have provided evidence supporting a role for CD4(+), CD8(+), and gammadelta TCR(+) T cells in the response of cattle to...

We report an 82 yr old man with isolated intrathoracic lymphadenopathy of tuberculous origin, which is an extremely uncommon presentation of tuberculosis especially in elderly Caucasian patients. The diagnosis was suggested by the computerized tomographic (CT)-scan showing central hypodense areas after contrast, and was subsequently proved by mediastinoscopic biopsy with histological and microb...

Granulomas are innate sequestration responses that can be modified by superimposed acquired immune mechanisms. The present study examined the innate stage of pulmonary granuloma responses to bead-immobilized Th1- and Th2-inducing pathogen antigens (Ags), Mycobacteria bovis purified protein derivative (PPD) and Schistosoma mansoni soluble egg Ags (SEA). Compared to a nonpathogen Ag, PPD and SEA ...

UNLABELLED The purpose of this study was to investigate if there is an inverse association between Mycobacterium tuberculosis infection and atopy among children living in rural and semi urban areas in El Behira governorate, Egypt. METHODS All the studied children were BCG vaccinated in their newborn period. In Tuberculin testing, indurations greater than or equal to 5 mm were accepted as posi...

57 year old man was admitted because of cystic lesions on his chest x-ray film (Fig 1). Eight months earlier, transitional cell carcinoma of the bladder, grade 3, was diagnosed, for which he received local irradiation, followed by radical cystectomy. There was no evidence of metastatic disease. On admission, the patient denied increased cough, sputum production, dyspnea, fever, weight loss, hem...

OBJECTIVES To describe a patient with tuberculous neuroretinitis. MATERIALS AND METHODS Retrospective case report. RESULTS We describe a 43-year-old otherwise asymptomatic woman with a known exposure to tuberculosis who had unilateral optic disc edema and a partial macular star (neuroretinitis). This was followed approximately 1 year later by the development of an exudative retinal detachme...