Abstract Purpose Gastroretentive drug delivery systems (GRDDS) have attracted interest for enhancement of absorption and bioavailability some drugs. Itopride hydrochloride (ITOP) is a used treatment gastroesophageal reflux other gastric motility disorders, but characterized by narrow window short in vivo half-life. Therefore, it expected that its formulation expanding gastroretentive tablets wo...

Alone and combined effects of cyclodextrins (βCD and HPβCD), surfactant (Tween-80) and PVP on the solubility and dissolution rate of etoricoxib were evaluated in a series of 2 factorial design. The complexes of etoricoxib – CDs (βCD and HPβCD) were prepared with and without Tween-80 and PVP by kneading method as per 2 factorial designs. The solubility of etoricoxib in eight selected fluids cont...

BACKGROUND Percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP) are effective procedures for the treatment of vertebral compression fractures (VCFs). However, recent studies have reported that secondary VCFs develop in patients after PVP or PKP treatment. This study aimed to investigate the clinical characteristics and management of secondary fractures after PVP or PKP. MATERI...

BACKGROUND Percutaneous vertebroplasty (PVP) for patients with chronic painful osteoporotic compression fractures has not been extensively studied. OBJECTIVE To prospectively evaluate the efficacy of PVP for patients with chronic painful osteoporotic vertebral compression fractures (VCFs). METHODS Sixty-two consecutive patients with chronic painful osteoporotic VCFs for ≥3 months underwent ...

Allografts eliminate the disadvantages associated with autografts and synthetic scaffolds but are associated with a disease-transmission risk. Therefore, allograft sterilisation is crucial. We aimed to determine whether polyvinylpyrrolidone-iodine (PVP-I) can be used for sterilisation and as a new wet-preservation method. PVP-I-sterilised and preserved allografts demonstrated improved mechanica...

Polyvinylpyrrolidone-iodine (PVP-I) is a broad-spectrum antimicrobial agent, but its effects on tendon-bone healing are unclear. The purpose of this study was to investigate the effects of PVP-I on bone marrow mesenchymal stem cells (BMSCs) in vitro and on tendon-bone healing in vivo. In this study, following investigation of the concentration-dependent effects of PVP-I on the viability and ost...

Electrospinning is a versatile technique, which can be used to generate nanofibers from a rich variety of materials. We investigate the variation of a zinc oxide (ZnO)-polyvinylpyrrolidone (PVP) composite structure in morphology by electrospinning from a series of mixture solutions of ZnO sol-gel and PVP. Calcination conditions for the crystallization of ZnO nanofibers and removal of the PVP co...