Geographic variations in mortality rate in the United States could be due to several hypothesized factors, one of which is exposure to solar ultraviolet radiation (UVR). Limited evidence from previous prospective studies has been inconclusive. The association between ambient residential UVR exposure and total and cause-specific mortality risks in a regionally diverse cohort (346,615 white, non-...

BACKGROUND Exposure to endocrine-disrupting chemicals, such as persistent organochlorine pesticides, has been suggested to increase the risk of testicular germ cell tumors (TGCTs). METHODS To study the relationship of POP exposure to TGCT risk, prediagnostic serum samples from 754 case subjects and 928 control subjects enrolled in the Servicemen's Testicular Tumor Environmental and Endocrine ...

IGF-I shares structural homology and in vitro metabolic activity with insulin. Laboratory models suggest that IGF-I and its binding proteins IGFBP-1 and IGFBP-2 have potentially beneficial effects on diabetes risk, whereas IGFBP-3 may have adverse effects. We therefore conducted a prospective nested case-control investigation of incident diabetes (n = 742 case subjects matched 1:1 to control su...

BACKGROUND The relationships between uric acid and metabolic syndrome (MetS) and diabetes, as well as the gender differences in these relationships are controversial. METHODS Medical check-up data from 2,449 Japanese men and 1,448 Japanese women were examined. The prevalence of MetS and diabetes was calculated by the quartiles of serum levels of uric acid. Correlation coefficients between uri...

The interactions between the boreal summer intraseasonal oscillation (ISO) and synoptic-scale variability (SSV) are investigated by diagnosing the atmospheric apparent heat source (Q1), apparent moisture sink (Q2), and eddy momentum transport. It is found that the synoptic Q1 and Q2 heating (cooling) anomalies are in phase with cyclonic (anticyclonic) vorticity disturbances, aligned in a southe...

BACKGROUND Utilization of cardiac services varies across regions and hospitals, yet little is known regarding variation in the intensity of outpatient cardiac care across cardiology physician practices or the association with clinical endpoints, an area of potential importance to promote efficient care. METHODS AND RESULTS We included 7 160 732 Medicare beneficiaries who received services fro...

BACKGROUND AND PURPOSE We investigate whether admission serum calcium levels are associated with hematoma volume, stroke severity, and outcomes in patients with acute intracerebral hemorrhage. METHODS A total of 273 patients admitted within 24 hours after intracerebral hemorrhage onset was divided into quartiles based on admission serum calcium levels (Q1 [≤9.0], Q2 [9.1-9.3], Q3 [9.4-9.7], Q...

We consider the parabolic obstacle type problem  Hu = fχΩ in Q − 1 , u = |∇u| = 0 on Q1 \ Ω, where Ω is an unknown open subset of Q1 . This problem has its origin in parabolic potential theory. When f is Hölder continuous we can, under a combination of energetic and geometric assumptions, prove the optimal C x ∩ C t regularity of the solution.

We will use immersed surfaces to study Seifert fibered surgery on Montesinos knots, and show that if 1 q1−1 + 1 q2−1 + 1 q3−1 ≤ 1 then a Montesinos knot K(p q1 , p2 q2 , p3 q3 ) admits no atoroidal Seifert fibered surgery.