PURPOSE Myopia is the most common visual problem in the world. High myopia, the extreme form of myopia that can be complicated by retinal detachment and macular degeneration, affects 1%-2% of the general population. The genes responsible for nonsyndromic high myopia have not been identified although several chromosome loci have been suggested. Additional loci for the majority of high myopia, es...

phenotypically normal females with secondary amenorrhea and translocation between Xq and Yq. To the best of our knowledge, the detection of Xq;Yq translocation at prenatal diagnosis has not been reported. Herein, we report the prenatal diagnosis of a de novo unbal­ anced Xq;Yq translocation for the first time and discuss issues in genetic counseling to be given to patients with this particular ...