Much human learning appears to be gradual and unconscious, suggesting a very limited form of search through the space of hypotheses. We propose hill climbing as a framework for such learning and consider a number of systems that learn in this manner. We focus on CLASSIT, a model of concept formation that incrementally acquires a conceptual hierarchy, and MAGGIE, a model of skill improvement tha...

DNA cross-linking technology is an attractive tool for the detection, regulation, and manipulation of genes. In this study, a series of photolabile 4-oxo-enal-modified oligonucleotides functionalized with photosensitive ο-nitrobenzyl derivatives were rationally designed as a new kind of photocaged cross-linking agents. A comprehensive evaluation of cross-linking reactions for different nucleoba...

Misdiagnoses and missed diagnoses of gifted students with co-occurring learning-, developmental behavioural disorders are often mentioned in literature practice. Consequently, these Twice-Exceptional (2E) fall between two stools regarding appropriate psycho-educational interventions. This article offers a research practice informed assessment procedure, namely the Strengths Weaknesses Heuristic...

Bottorff JL, Johnson JL, Moffat B, et al. Synchronizing clinician engagement and client motivation in telephone counseling. Qual Health Res 2004;14:462–77. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....

BACKGROUND Patients with chronic obstructive pulmonary disease (COPD) often report inadequate access to comprehensive patient education resources. OBJECTIVE The purpose of this study was to incorporate community-engagement principles within a mixed-method research design to evaluate the usability and acceptability of a self-tailored social media resource center for medically underserved patie...

The complete mol-ecule of the title compound, C(16)H(14)O(3), is generated by crystallographic mirror symmetry, with two C atoms and one O atom lying on the mirror plane. The mol-ecule adopts an E configuration about the C=C bond and the dihedral angle between the furan rings is 16.1 (2)°.

Limb-girdle muscular dystrophy type 2E (LGMD-2E) is caused by autosomal recessive defects in the beta sarcoglycan (SGCB) gene located on chromosome 4q12. In this case report, the clinical findings, histopathological features and molecular genetic data in a boy with β sarcoglycanopathy are presented. An 18-month-old boy had a very high serum creatinine phosphokinase (CPK) level that was accident...