The concept of correlating pharmacokinetic parameters with body weight from different animal species has become a useful tool in drug development. The allometric approach is based on the power function, where the body weight of the species is plotted against the pharmacokinetic parameter(s) of interest. Clearance, volume of distribution, and elimination half-life are the three most frequently e...

Introduction We investigate discovery in pharmacology by following and analyzing the progress of research on drugs for Parkinson’s disease at our local pharmacology department. In pharmacology research detailed knowledge of biological processes is used to provide a rationale for a desired biological activity of a drug. This desired activity should cause a decrease in disease symptoms and is cal...

The article presents a constructive scheme of multifunctional seeding apparatus and substantiates the relevance its use for agricultural producers Southern Federal district with total area arable land up to 50-70 hectares. This machine allows sowing in various ways each crop. To assess qualitative performance Kuban State University named after I. T. Trubilin, private methodology experimental se...

We present the device parameters for organic field-effect transistors fabricated from solution-deposited films of functionalized pentacene and anthradithiophenes. These materials are easily prepared in one or two steps from commercially available starting materials and are purified by simple recrystallization. For a solution-deposited film of functionalized pentacene, hole mobility of 0.17 cm2/...

Diierential cross sections for pp elastic scattering have been measured for very small momentum transfers at six diierent incident antiproton momenta in the range 3.7 to 6.2 GeV/c by the detection of recoil protons at scattering angles close to 90. Forward scattering parameters T , b, and have been determined. For the-parameter, up to an order of magnitude higher level of precision has been ach...

The introduction of internet auction has significantly widened the pool of consumers who participate in auctions and increased the number of companies attempting to sell their products in an auction format. Previous empirical research on auctions has focused almost exclusively on the behavior of professional bidders. In this study, we collect data on a large number of internet auctions to explo...

In integrable field theories the S-matrix is usually a product of a relatively simple matrix and a complicated scalar factor. We make an observation that in many relativistic integrable field theories the scalar factor can be expressed as a convolution of simple kernels appearing in the nested levels of the nested Bethe ansatz. We formulate a proposal, up to some discrete ambiguities, how to re...