Although tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has shown efficacy in a phase 2 clinical trial, development of resistance to TRAIL by tumor cells is a major roadblock. We investigated whether quercetin, a flavonoid, can sensitize human ovarian cancer cells to TRAIL. Results indicate that quercetin sensitized cancer cells to TRAIL. The quercetin induced expression of dea...

Quercetin was previously reported to exhibit significant anti-proliferative activities, and its major effect on tumors was to induce cell apoptosis or autophagy. However, the specific mechanism remains controversial. In this study, autophagy induced by quercetin was determined with various methods. Intracellular Ca2+ ([Ca2+]i) was measured after being incubated with Fluo-3 acetoxymethyl (AM). A...

A chemical behavior of Quercetin as antioxidant and metal chelator has become the subject of intense experimental research. In this paper, we apply a semi empirical approach to study the stability constant of Quercetin with metals like Cd, Pb and Bi. The comparative analysis of the theoretical formation constant of Quercetin-metal complexes with metals with experimental results shows that H-rem...

Background and Purpose: The aim of this study is to examine the migration, wound healing, colony formation cytotoxic effects reynotrin, quercetin derivative, in breast cancer cells. Methods: In our study, CRL-4010, MCF7 MDA-MB-231 cells were used evaluate different reynoutrin on cancer. IC50 concentration (400 µg/ml) cisplatin was determined. For cytotoxicity assessments, varying concentrations...

− A new quercetin 3-O-trisaccharide was isolated from the leaves of Rubus crataegifolius (Rosaceae). The structure of this compound was determined as quercetin 3-O-α-L-arabinofuranosyl-(1→ 2)-β-D-xylopyranosyl(1→ 2)-β-D-galactopyranoside on the basis of 2D-NMR spectroscopic data. This flavonol glycoside was isolated for the first time from a natural source.

Quercetin is a major dietary flavonoid found in onions and other vegetables. It is known that dietary quercetin is metabolized in the intestinal mucosa and the liver and is present as its glucuronide/sulfate conjugates with or without methylation. Although quercetin is known to possess strong antioxidant activity, there are only limited reports on the antioxidant activity of its metabolites. In...

Naturally occurring compounds are considered as attractive candidates for cancer treatment and prevention. Quercetin and ellagic acid are naturally occurring flavonoids abundantly seen in several fruits and vegetables. In the present study, we evaluate and compare antitumor efficacies of quercetin and ellagic acid in animal models and cancer cell lines in a comprehensive manner. We found that q...

From the needles of Taxus baccata the following flavonoids were isolated: 3-O-rutinosides quercetin, myricetin and kaempferol, 7-O-glucosides kaempferol and quercetin, kaempferol, quercetin, myricetin. The composition of flavonols and biflavones in some of the species of the genus Taxus, namely T. celebica, T. cuspidata, T. media and cultivar varieties T. baccata 'Aurea', T. baccata 'Aurea deco...

Quercetin is a dietary flavonoid which has anti-inflammatory effects. This study aimed to evaluate the influence of quercetin on histopathological aspects and airway epithelium in  allergic airway  inflammation mice model. Twenty-eight BALB/c mice were randomly divided into four groups: Group I (control), Group II (untreated mice with allergic airway inflammation), Group III (allergic airway in...