developed fever, and was sent to hospital. In hospital he had daily attacks of ague, for which he was treated with quinine, " eight pills three times a day." The quinine caused deafness, but as the fever was not influenced he was shipped to Jamaica on his way to England. During the voyage he was still treated with quinine, but the fever became worse, and he was disembarked at Kingston and sent ...

Behavioral and electrophysiological studies suggest that rats can identify a taste stimulus with a single lick, in <200 ms. However, the conditions under which these conclusions were drawn varied widely across experiments. We designed a series of experiments to assess the effects of the number of licks of a tastant that are available, tastant concentration and prior learning experience on the s...

Impacts of plant invasions are largely scale-dependent and responses to the same exotic species may vary among communities. Since impacts caused by individual trees could anticipate consequences of a closed canopy of an invader, we studied the response of Galápagos native plants to quinine (Cinchona pubescens) trees in two vegetation zones. Quinine has invaded >11,000 ha of Santa Cruz Island, i...

In a study of intramuscular injection of quinine eight adults with moderately severe falciparum malaria resistant to chloroquine were treated with quinine dihydrochloride, being given a loading dose of 20 mg salt (16.7 mg base)/kg followed by three or four eight hourly maintenance doses of 10 mg salt (8.3 mg base)/kg injected into the anterior thigh. All patients responded to treatment. Fever a...

The fact that quinine is used to overcome uterine inertia in weak women, and as an ecbolic is always prescribed during labour, if there is no obstruction, is mainly responsible for the general impression that its use should be avoided during pregnancy as far as possible. Clinical experience, however, warrants no such fear about the administration of quinine during pregnancy. Hare, in his Practi...