Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcriptional factor that regulates many antioxidants, and we have recently succeeded in obtaining a novel Nrf2 activator, RS9, from microbial transformation. RS9 is categorized as a triterpenoid, and well-known triterpenoids such as RTA 402 (bardoxolone methyl) and RTA 408 have been tested in clinical trials. RTA 408 lotion is currently...

skin disorders comprise more than 35% of all occupationally related diseases. 90-95% of work-related dermatoses are contact dermatitis. effects of occupational dermatitis in the lives of workers are substantial. to plan any preventive program we need basic statistics of the problem, that we had no reliable one which includes a lot of industries in iran. therefore we decided to determine occupat...

Cancer patients had limited treatment options for decades, such as surgery, chemotherapy, and radiation therapy, alone or combined. However, there have been substantial improvements in recent years with the introduction of stem cell hormone anti-angiogenic treatments, immunotherapy, dendritic cell-based targeted ablation nanoparticles, natural antioxidants, radionics, chemodynamic sonodynamic f...

BACKGROUND Contact dermatitis is one of the common work-related dermatoses. Among bricklayers, cement can cause both allergic contact dermatitis and primary contact irritative dermatitis. The personal protective equipment (rubber gloves) may favor the development of allergic contact dermatitis. OBJECTIVES 1) to evaluate the frequency of allergic contact dermatitis among construction workers b...

BACKGROUND To evaluate the association between single nucleotide polymorphisms (SNPs) at the 194 and 399 codons of XRCC1, and the risk of severe acute skin and oral mucosa reactions in nasopharyngeal carcinoma patients in China. METHODS 114 patients with nasopharyngeal carcinoma were sequentially recruited in this study. Heparinized peripheral blood samples were taken for SNPs analysis before...

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INTRODUCTION Urea is an organic compound that has been used clinically for dermatological diseases for more than a century. Urea is a potent emollient and keratolytic agent, making urea an effective monotherapy for conditions associated with dry and scaly skin. A systematic review of the literature is needed to provide clinicians with evidence-based applications of urea in the treatment of derm...

objective: there is some evidence that chronic skin diseases like dermatitis could affect the quality of life of sufferers. in addition, patients with dermatological disorders are at greater risk to develop psychiatric morbidity. the aim of this study was to explore the quality of life in patients with chronic eczematous dermatitis. we also examined the effect of a convenient dermatologic inter...

Abstract Radiation recall dermatitis (RRD) is an extremely rare phenomenon. A variety of factors such as antineoplastic agents, pharmaceutical physical and environmental have been proposed to be the underlying cause RRD. Only a handful cases reported till date, where trastuzumab sought triggering agent. The presentation RRD varies from mild erythematous extensive confluent dermatitis, resolving...