Introduction Radioiodine is a safe and effective treatment for Graves’ disease. Iatrogenic hypothyroidism is very common after treatment, but its onset is unpredictable. Even a short episode of hypothyroidism can result in significant morbidity and ideally should be avoided. In Newcastle a standard dose of radioiodine (400MBq) is used, but for historical reasons two different protocols are used...

Radioiodine-concentrating activity in thyroid tissues has allowed the use of radioiodine as a diagnostic and therapeutic agent for patients with thyroid disorders such as well-differentiated thyroid cancer. However, some extrathyroidal tissues also take up radioiodine, contributing to unwanted side effects of radioiodine therapy. Now that the molecule that mediates radioiodine uptake, the sodiu...

OBJECTIVE: To evaluate the changes in clinical parameters and in the approach to patients submitted to radioiodine therapy for Graves’ disease. MATERIALS AND METHODS: Dossiers of 226 patients submitted to radioiodine therapy for Graves’ disease in the period between January 1990 and December 2001 were retrospectively evaluated. For the purposes of statistical analysis, the 12-year period was su...

OBJECTIVE To evaluate the effects of pretreatment with the retinoid X receptor (RXR) agonist bexarotene on the efficacy of radioiodine therapy for metastases of differentiated thyroid carcinoma (DTC) with limited uptake of radioiodine (I-131). DESIGN An open prospective intervention study. METHODS Eight patients with metastases of DTC, with insufficient uptake of I-131 who showed increased ...

The presented work describes the thyroid pathologies and nuclear-medical diagnostic approach, in order to obtain a differential diagnosis monitoring of various neoplasms; specifically, it importance radiometabolic treatment with iodine 131, after thyroidectomy surgery. Through study conducted patients suffering from disease, undergoing metabolic radiotherapy, is shown that, equal distribution r...

Unexpected reactor accidents and radioisotope production and consumption have led to a continuous increase in the global-scale contamination of radionuclides. In particular, anthropogenic radioiodine has become critical due to its highly volatile mobilization and recycling in global environments, resulting in widespread, negative impact on nature. We report a novel biostimulant method to effect...

Findings on palpation are not always a guide to the true functional findings and the cause of hyperthyroidism. Our results supported this, with only 40 out of 63 cases being correctly diagnosed before the thyroid scan was obtained. Early diagnosis is particularly important in view of the excellent results achieved with radioiodine. Recent follow up studies (paper in preparation) of treatment of...

introduction:  the use of radioactive iodine (131i) has become an important adjunct to the treatment of thyroid cancer and hyperthyroidism. salivary gland has the ability to concentrate radioactive iodine under normal circumstances. salivary gland dysfunction and dry mouth are the common side effectsof high-dose radioiodine therapy. the purposeof this study was to determine the absorbed dose of...

Introduction. Although follicular thyroid carcinoma is a rare malignant tumor, up to 20% of the patients are threatened by potential complications resulting from infiltrating tumor growth into surrounding tissues. Case report. A 66year-old female came to hospital with the presence of a growing thyroid nodule of the left lobe. Ultrasonic examination showed a 8 cm hypoechoic nodule in the left lo...

Diagnostic whole-body scan is a standard procedure in patients with thyroid cancer prior to the application of a therapeutic dose of 131I. Unfortunately, administration of the radioisotope in a diagnostic dose may decrease further radioiodine uptake-the phenomenon called "thyroid stunning". We estimated radiation absorbed dose-dependent changes in genetic material, in particular in the sodium i...