One of the most common problems associated with radiopharmaceuticals is an unanticipated or altered biodistribution, which can have a significant clinical impact on safety, scan interpretation, and diagnostic imaging accuracy. In their most extreme manifestations, unanticipated imaging results may even compromise the utility and or accuracy of nuclear medicine studies. We present here an overal...

The proposed model describes in a quality way the process of tumor-imaging radiopharmaceutical 99mTc-MIBI distribution with taking into account radiopharmaceutical accumulation, elimination, and radioactive decay. The dependencies of concentration versus the time are analyzed. The model can be easily tested by the concentration data of the radioactive pharmaceuticals in the blood measured at ea...

Introduction: Nuclear Scintigraphy is a highly sensitive, alternative imaging modality used in human and veterinary medicine. This modality involves the administration of a radioactive substance (radioisotope) to a patient. Generally, the radioisotope is labeled to a specific compound. This labeled combination is known as a radiopharmaceutical. These radiopharmaceuticals are formulated in vario...

The off-label use of bevacizumab labeled with 99mTc as a new radiopharmaceutical for imaging of endometriosis is a promising noninvasive, new clinical procedure. The bevacizumab in monoclonal antibodies targeted at vascular endothelial growth factor (VEGF) is superexpressed in cases of endometriosis. In this study we evaluate the imaging of endometriosis lesion in rats (induced to endometriosis...

UNLABELLED Iodine-123-beta-CIT is a SPECT radioligand for dopamine and 5-HT transporters with potential use in Parkinson's disease, schizophrenia and cocaine addiction studies. At present, preparation of no-carrier-added (NCA) [123I] beta-CIT is achieved by iododestannylation of a trialkylstannyl precursor with sodium [123I]iodide in the presence of oxidizing agent, followed by preparative HPLC...

The adrenal cortical enzyme systems, 11 beta-hydroxylase, P-450 11 beta, and the side-chain cleavage complex, P-450 scc, differ only in their cytochrome P-450s. Structural modifications of metyrapone, an inhibitor of cytochrome P-450 enzyme systems, have been made to determine the requirement for the A- or B-pyridyl ring for inhibition of P-45011 beta and P-450 scc activities. Three new analogs...

Introduction In 2016, our center adopted technology to routinely monitor 18 F-FDG radiopharmaceutical administrations. Within six months of following basic quality improvement methodology, technologists reduced extravasation rates from 13.3% 2.9% ( p < 0.0001). These same administer other radiopharmaceuticals (without monitoring technology) for general nuclear medicine procedures in a se...

BACKGROUND AND THE PURPOSE OF THE STUDY Technetium-99m is the major radionuclide used in the world and mainly is provided by fission product. However extensive research has been conducted on the use of accelerators for production of (99m)Tc. This investigation reports the production of (99m)Tc radioisotope using cyclotrons and the preparation, quality control and biodistribution studies of four...