Osteoblastic metastases and osteosarcoma can avidly concentrate bone-seeking radiopharmaceuticals. We sought to increase effectiveness of high-dose (153)Samarium ethylenediaminetetramethylenephosphonate (153Sm-EDTMP, Quadramet) on osteosarcomas using a radiosensitizer, gemcitabine. Fourteen patients with osteoblastic lesions were treated with 30 mCi/kg 153Sm-EDTMP. Gemcitabine was administered ...

Bioreductively-Activated Prodrugs of Nitric Oxide (NO) Harinath Chakrapani and Kavita Sharma Indian Institute of Science Education and Research, India Approximately one-third of human tumours contain areas with limited oxygen tension (hypoxia) in comparison with normal cells. As oxygen is a potent radiosensitizer, hypoxic tumours are often less responsive to radiation treatment. Due to diminish...

Purpose: In radiation therapy, gold nanoparticles (GNPs) are regarded as a promising radiosensitizer candidate. Several studies have revealed a dose enhancement by GNPs in X-ray and even proton irradiation. However, these studies have been limited to the depth direction. The dose distribution in both depth and lateral directions is crucial to evaluate the full radio sensitizing effect. The purp...

Abstract Magnetic spinel ferrite nanoparticles (SFNPs) attract high scientific attention from researchers due to their broad area for biomedicine applications, comprising cancer magnetic hyperthermia and targeted drug delivery. Uniquely, its excellent performance, namely, tuning size surface morphology, magnetism, extraordinary magnetically heat induction, promising biocompatibility, specific t...

Nutlin-3 is a small-molecule inhibitor that acts to inhibit MDM2 binding to p53 and subsequent p53-dependent DNA damage signaling. Whether Nutlin-3 alters cell toxicity following DNA damage under oxic versus hypoxic conditions has not been studied. The potential radiosensitization (0-10 Gy) properties of Nutlin-3 (dose range, 2-10 micromol/L for up to 24 h) were investigated in vitro using thre...