نتایج جستجو برای: randomized clinical trials
تعداد نتایج: 1402305 فیلتر نتایج به سال:
Achieving success in the development of a cancer drug continues to be challenging. Given the increasing costs (1) and the small number of drugs that gain regulatory approval (2), it is crucial to understand these failures. In this issue of the Journal, Gan et al. (3) reviewed 235 recently published phase III randomized clinical trials (RCTs). They report that 62% of the trials did not achieve r...
Several chemical substances belonging to classes of natural dietary origin display protective properties against some age-related diseases including neurodegenerative ones, particularly Alzheimer's disease (AD). These compounds, known as nutraceuticals, differ structurally, act therefore at different biochemical and metabolic levels and have shown different types of neuroprotective properties. ...
Evidence plays a crucial role in scientific activity. In this chapter, we discuss this notion in the context of evidence-based approaches to medical research. Nancy Cartwright has correctly emphasized why randomized clinical trials (RCTs) are not the gold standard in medicine (see, e.g., Cartwright 2009, 2010; Cartwright and Hardie 2012; additional skepticism regarding the alleged epistemic sup...
OBJECTIVE The aim of this systematic review was to compare the clinical effectiveness of systemic antibiotics administered in the active stage of periodontal treatment or after the healing phase. MATERIAL AND METHODS An electronic search was performed in the databases EMBASE, MEDLINE and Cochrane Central Register of Controlled Trials (CENTRAL), in accordance with the Preferred Reporting Items...
BACKGROUND Informal caregivers (CGs) of patients with Alzheimer's disease are at risk of suffering from psychological and physical weakening. Several psychoeducational interventions have been designed to prevent stress and burden of caregivers. In France, despite health authorities' recommendations, to our knowledge there is no rigorously assessed Web-based psychoeducational program to date. ...
Placebos are indispensable controls in randomized clinical trials (RCTs), and placebo responses significantly contribute to routine clinical outcomes. Recent neurophysiological studies reveal neurotransmitter pathways that mediate placebo effects. Evidence that genetic variations in these pathways can modify placebo effects raises the possibility of using genetic screening to identify placebo r...
A recent meta-analysis of selected randomized clinical trials (RCTs), in which population groups of differing ages and health status were supplemented with various doses of β-carotene, vitamin A, and/or vitamin E, found that these interventions increased all-cause mortality. However, this meta-analysis did not consider the rationale of the constituent RCTs for antioxidant supplementation, none ...
BACKGROUND Randomized clinical trials (RCTs) stopped early for benefit often receive great attention and affect clinical practice, but pose interpretational challenges for clinicians, researchers, and policy makers. Because the decision to stop the trial may arise from catching the treatment effect at a random high, truncated RCTs (tRCTs) may overestimate the true treatment effect. The Study Of...
Randomized clinical trials (RCTs) are the most appropriate research design for studying the effectiveness of a specific intervention. Its results are considered as the highest 'level of evidence'. Published reports on RCTs have already succeeded in a peer review process, but still there can be undetected major deficiencies of the study that may question the reported outcome. It is still up to t...
CTS Sleep Disordered Breathing Committee Correspondence: Dr John Fleetham, Respiratory Medicine, 7th Floor, Diamond Health Care Centre, 2775 Laurel Street,Vancouver, British Columbia V5Z 1M9. Telephone 604-875-5653, fax 604-875-5587, e-mail [email protected] T Canadian Thoracic Society (CTS) guidelines for the diagnosis and treatment of sleep disordered breathing in adults were developed ove...
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