Cyanide binding to cytochrome c oxidase has been investigated by sequential mixing and rapid scan stopped flow spectroscopy. Double mixing experiments confirm earlier reports that cyanide binds rapidly to partially reduced enzyme species formed in turnover. The absorbance/time/wavelength matrices, captured during the onset of cyanide inhibition of cytochrome c oxidase by rapid scan stopped flow...

The Gibbs sampler is a particularly popular Markov chain used for learning and inference problems in Graphical Models (GMs). These tasks are computationally intractable in general, and the Gibbs sampler often suffers from slow mixing. In this paper, we study the SwendsenWang dynamics which is a more sophisticated Markov chain designed to overcome bottlenecks that impede the Gibbs sampler. We pr...

This study presents a novel acoustic mixer comprising of a microfabricated silicon nitride membrane with a hole etched through it. We show that the introduction of the through hole leads to extremely fast and homogeneous mixing. When the membrane is immersed in fluid and subjected to acoustic excitation, a strong streaming field in the form of vortices is generated. The vortices are always obse...

Information on the time-dependence of molecular species is critical for elucidating reaction mechanisms in chemistry and biology. Rapid flow experiments involving turbulent mixing of two or more solutions continue to be the main source of kinetic information on protein folding and other biochemical processes, such as ligand binding and enzymatic reactions. Recent advances in mixer design and de...

Gibbs sampling is a Markov chain Monte Carlo technique commonly used for estimating marginal distributions. To speed up Gibbs sampling, there has recently been interest in parallelizing it by executing asynchronously. While empirical results suggest that many models can be efficiently sampled asynchronously, traditional Markov chain analysis does not apply to the asynchronous case, and thus asy...

Recently, David Chaum proposed an electronic voting scheme that combines visual cryptography and digital processing. It was designed to meet not only mathematical security standards, but also to be accepted by voters that do not trust electronic devices. In this scheme mix-servers are used to guarantee anonymity of the votes in the counting process. The mix-servers are operated by different par...

This paper reports the investigation of mixing phenomena caused by the interaction between a uniform magnetic field and a magnetic fluid in a microfluidic chamber. The flow system consists of a water-based ferrofluid and a mixture of DI water and glycerol. Under a uniform magnetic field, the mismatch in magnetization of the fluids leads to instability at the interface and subsequent rapid mixin...

Ge and Štefankovič have recently introduced a novel two-variable graph polynomial. When specialised to a bipartite graphs G and evaluated at the point ( 2 , 1) this polynomial gives the number of independent sets in the graph. Inspired by this polynomial, they also introduced a Markov chain which, if rapidly mixing, would provide an efficient sampling procedure for independent sets in G. This s...

The control for the processing of precursor liquids determines whether the properties and functions of the final material product can be engineered. An inherent challenge of processing viscous liquids arises from their large resistance to deform. Here, we report on the discovery of an electric approach that can significantly contribute to address this challenge. The applied electric force can i...

A famous result of Bayer and Diaconis [2] is that the Gilbert-Shannon-Reeds (GSR) model for the riffle shuffle of n cards mixes in 3 2 log2 n steps and that for 52 cards about 7 shuffles suffices to mix the deck. In this paper, we study variants of the GSR shuffle that have been proposed to model more realistically how people actually shuffle a deck of cards. The clumpy riffle shuffle and deale...