Extreme events such as natural or technological disasters challenge society’s capabilities for planning and response. While advanced technologies and modeling techniques continue to expand how society can limit and manage extreme events, flexibility and an ability to improvise remain crucial in responding to them. By analyzing a case from the response to the 2001 World Trade Center attack, this...

Working-group members: Ilham Al Mahamid, Lawrence Berkeley National Laboratory; John Bargar, Stanford Linear Accelerator Center; Sally Benson, Lawrence Berkeley National Laboratory; Paul Bertsch, University of Georgia; Sharon Borglin, Lawrence Berkeley National Laboratory; Susan Carroll, Lawrence Livermore National Laboratory; Scott Chambers, Pacific Northwest National Laboratory; Sing-Foong Ch...

ALTHOUGH actinomycosis is believed to be a rare disease, an increasing number of case reports suggest that this may not be so. Many cases may not be recognised, because of their abortion by the widespread use of antilbiotics. Another pitfall in the diagnosis is the failure to obtain anaerobic cultures in suspected cases (Shah 1971). A presentation with some unusual features is described and som...

Ebstein malformation is a rare disease that presents with a spectrum of severity. We use a management paradigm that breaks the anomaly into two groups: neonates and children/adults. This leads to a discussion of management and operative techniques as well as pitfalls. We hope the reader finds our streamlined and logical approach of benefit to this complex and rare disease.

A methodology is proposed for studying rare events in stochastic partial differential equations in systems that are so large that standard large deviation theory does not apply. The idea is to deduce the behavior of the original model by breaking the system into appropriately scaled subsystems that are sufficiently small for large deviation theory to apply but sufficiently large to be asymptoti...

Lymphangioleiomyomatosis (LAM) and pulmonary Langerhans cell histiocytosis (PLCH) are rare diseases that lead to progressive cystic destruction of the lungs. Despite their distinctive characteristics, these diseases share several features. Patients affected by LAM or PLCH have similar radiological cystic patterns, a similar age of onset, and the possibility of extrapulmonary involvement. In thi...

Resources for rare diseases are lacking. Patients do not have the information and support that they need, and researchers struggle to make progress due to a shortage of skills and collaborations within the field. One way to overcome these hurdles is to host annual Symposia, focused on a specific rare disease. Here, we use the example of Birt-Hogg-Dubé Symposia to discuss the practical issues of...

Cap polyposis is a rare disorder with characteristic endoscopic and histological features; its etiology is still unknown, and no specific treatment has been established. We report a case of cap polyposis that improved remarkably after infliximab infusion and had no recurrence for 3 years.

Indicators for Absolute Sustainability To Support Development within Planetary Boundaries Anders Bjørn,*,† Miriam Diamond,‡ Mikołaj Owsianiak,† Benoît Verzat, and Michael Zwicky Hauschild† †DTU Management Engineering, Quantitative Sustainability Assessment, Technical University of Denmark, Produktionstorvet, Building 424, 2800 Kgs. Lyngby, Denmark ‡Department of Earth Sciences, University Of To...