Fenton RA, Komatsu S, Ikebe M, Shea LG, Dobson JG, Jr. Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-ε to RACK2 in adult rat and mouse. Am J Physiol Heart Circ Physiol 297: H718–H725, 2009. First published June 12, 2009; doi:10.1152/ajpheart.00247.2009.—Adenosine protects the heart from adrenergic overstimulation. This adenoprotection includes...

Pressure-overloaded myocardial hypertrophy is an independent risk factor for various cardiovascular diseases (CVDs), such as heart failure (HF), arrhythmia, and even sudden death. It reported that QiShenYiQi pill (QSYQ) widely used in the treatment of CVDs can prevent pathological myocardium, but its specific mechanism still unclear. In this study, a rat model was established through pressure o...

Heated debate has surrounded the issue of whether adult stem cells can differentiate into cardiac myocytes and contribute to the function of the heart. In this issue of Cell, demonstrate stem cells in the adult rat heart that differentiate into cardiac myocytes in vitro and, when injected into the adult rat heart, can reconstitute the injured myocardium and improve function. These findings shou...

The regulatory properties of NAD(+)-isocitrate dehydrogenase and oxoglutarate dehydrogenase in extracts of yeast and rat heart mitochondria were studied under identical conditions. Yeast NAD(+)-isocitrate dehydrogenase exhibits a low K0.5 for isocitrate and is activated by AMP and ADP, but is insensitive to ATP and Ca2+. In contrast, the rat heart NAD(+)-isocitrate dehydrogenase was insensitive...

Heart transplantation remains the only curative treatment for end-stage heart failure. This life-saving option continues to be limited by low number of organ donors, graft rejection and adverse effects immunosuppressants. Engineering bioartificial hearts from acellular native-derived scaffolds stem cells has gained attention because its potential overcome these limitations. In this study, rat (...

Abstract Background Leptin exerts both protective and deleterious effects on the heart; first occurs under hypoxia- or ischemia-associated damage, second is a pro-hypertrophic factor cardiomyocytes. Therefore, leptin could represent link between obesity cardiovascular diseases. The study aimed to investigate effect of leptin—the same concentration that frequently measured in induces cardiac hyp...