We investigated the nutritional state of B vitamins and the neuropsychological functions in 25 subjects, aged 63.1 +/- 6.3 years, residing in rural areas of Korea. Nutritional states of thiamin, riboflavin, and pyridoxine were assessed enzymatically in the erythrocytes, and folate concentrations were measured microbiologically in the plasma and erythrocytes. A battery of composite neuropsycholo...

Background: Megaloblastic anaemia is one of the frequently occurring diseases in a developing country such as India. anemia occurs mainly because vitamin B12 and folate deficiency. Proper clinical assessment megaloblastic very important for diagnosis treatment. Aim Objective: profile different age group, central Indian population. Material &Methods: A cross-sectional, observational study wa...

BACKGROUND The prevalence of neural tube defects (NTDs) in northern China remains high after 10 years since periconceptional supplementation with folic acid has been known to be effective in reducing the risk of NTDs. OBJECTIVE The objectives of this study were to characterize folic acid awareness and use and to examine the association between folic acid supplementation with blood folate conc...

Erythrocyte (RBC) folates occur mainly as 5-methyltetrahydrofolate polyglutamates. Determination of RBC folate concentration requires an initial deconjugation of these polyglutamates. In this study, existing HPLC methods were adapted to investigate the rate and extent of this deconjugation process. The action of endogenous plasma pteroylpolyglutamate hydrolase activity was strongly affected by ...

BACKGROUND Better macro and micro nutrient status and their adequate intake by the athletes have great role in balancing losses associated with strenuous exercise, then for better performance. The objective of this study was to determine iron, folate and vitamin B12 status of Ethiopian professional athletes. METHODS A cross sectional study was conducted using a point time convenient sample of...

BACKGROUND AND OBJECTIVES Folate deficiency in the general population is associated with a risk of cardiovascular disease and various cancers. The aim of this study was to evaluate folate status in Italian blood donors and its relationship with gender and smoking habit. DESIGN AND METHODS A prospective study of 201 first visit donors (99 males and 102 females) was undertaken to evaluate folat...

Erythrocyte (RBC) folates occur mainly as 5-methyltetrahydrofolate polyglutamates. Determination of RBC folate concentration requires an initial deconjugation of these polyglutamates. In this study, existing HPLC methods were adapted to investigate the rate and extent of this deconjugation process. The action of endogenous plasma pteroyl-polyglutamate hydrolase activity was strongly affected by...

Folate deficiency can cause chromosome damage, which could result from reduced de novo thymidylate synthesis or DNA hypomethylation. High folic acid intake has been hypothesized to inhibit folate-dependent one-carbon metabolism, which could also lead to DNA damage. A large proportion of the general population may have high folic acid intakes. In this study, 2 experiments were conducted to exami...

background: the human immunodeficiency virus (hiv) is one of the most life- threatening human infections. the advent of highly active antiretroviral therapy (haart) has dramatically changed the course of hiv infection and patients' quality of life. in addition to the benefits, haart can have numerous side effects and toxicities. therefore, we aimed to assess the impact of short-term vitamins tr...

Background: The human immunodeficiency virus (HIV) is one of the most life- threatening human infections. The advent of highly active antiretroviral therapy (HAART) has dramatically changed the course of HIV infection and patients' quality of life. In addition to the benefits, HAART can have numerous side effects and toxicities. Therefore, we aimed to assess the impact of short-term vitamins tr...