نتایج جستجو برای: rbe

تعداد نتایج: 686  

2010
D. Pignalosa S. Ritter M. Durante

Introduction Cancer risk following exposure to energetic heavy ions is a major issue for space exploration and cancer ion beam therapy (1). However, no epidemiological data for exposure to heavy ions are available. Papillary thyroid carcinoma (PTC) is a known radiation-induced tumour. Several molecular studies have been performed to investigate genes involved in PTC occurrence. Rearrangements i...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2000
L W Hung E L Holbrook S R Holbrook

The crystal and molecular structure of an RNA duplex corresponding to the high affinity Rev protein binding element (RBE) has been determined at 2.1-A resolution. Four unique duplexes are present in the crystal, comprising two structural variants. In each duplex, the RNA double helix consists of an annealed 12-mer and 14-mer that form an asymmetric internal loop consisting of G-G and G-A noncan...

2014
A. O. Ezzati Y. Xiao M. Sohrabpour M. T. Studenski

Purpose: To quantify the DNA damage induced in a clinical megavoltage photon beam at various depths in and out of the field. Methods and Materials: MCNPX was used to simulate 10x10 cm and 20x20 cm 10 MV photon beams from a clinical linear accelerator. Photon and electron spectra were collected in a water phantom at depths of 2.5, 12.5 and 22.5 cm on the central axis and at off-axis points out t...

Journal: :Physics in Medicine & Biology 2021

2014
Daniel Habermehl Katarina Ilicic Sarah Dehne Stefan Rieken Lena Orschiedt Stephan Brons Thomas Haberer Klaus-Josef Weber Jürgen Debus Stephanie E. Combs

BACKGROUND Aim of this study was to evaluate the relative biological effectiveness (RBE) of carbon (12C) and oxygen ion (16O)-irradiation applied in the raster-scanning technique at the Heidelberg Ion beam Therapy center (HIT) based on clonogenic survival in hepatocellular carcinoma cell lines compared to photon irradiation. METHODS Four human HCC lines Hep3B, PLC, HepG2 and HUH7 were irradia...

2018
Thomas Tessonnier Andrea Mairani Wenjing Chen Paola Sala Francesco Cerutti Alfredo Ferrari Thomas Haberer Jürgen Debus Katia Parodi

BACKGROUND Due to their favorable physical and biological properties, helium ion beams are increasingly considered a promising alternative to proton beams for radiation therapy. Hence, this work aims at comparing in-silico the treatment of brain and ocular meningiomas with protons and helium ions, using for the first time a dedicated Monte Carlo (MC) based treatment planning engine (MCTP) thoro...

2016
Kris Armoogum Simon Evans David Morgan

PURPOSE We present a framework, in which we compare a conventional standard dose of 50 Gy in 25 fractions with accelerated partial breast irradiation (APBI) using electronic brachytherapy (eBT). We discuss how radiobiological modelling enables us to establish a framework, within which we can compare external beam radiotherapy (EBRT). This leads to a determination of the shell of isoeffect in br...

Journal: :Anticancer Research 2021

Background/Aim: We aimed to evaluate the clinical outcomes of oligometastatic colorectal cancer in liver and lung treated with carbon-ion radiotherapy (C-ion RT). Patients Methods: Nineteen consecutive patients or who received C-ion RT were analyzed. The doses 60.0 Gy [relative biological effectiveness (RBE)] 4 fractions, (RBE) 12 64.8 (BRE) fractions. Results: median follow-up duration was 19 ...

Journal: :Canadian journal of physiology and pharmacology 2001
J P Pignol J Slabbert

Fast neutrons (FN) have a higher radio-biological effectiveness (RBE) compared with photons, however the mechanism of this increase remains a controversial issue. RBE variations are seen among various FN facilities and at the same facility when different tissue depths or thicknesses of hardening filters are used. These variations lead to uncertainties in dose reporting as well as in the compari...

2014
Wataru Takahashi Shinichiro Mori Mio Nakajima Naoyoshi Yamamoto Taku Inaniwa Takuji Furukawa Toshiyuki Shirai Koji Noda Keiichi Nakagawa Tadashi Kamada

BACKGROUND To moving lung tumors, we applied a respiratory-gated strategy to carbon-ion pencil beam scanning with multiple phase-controlled rescanning (PCR). In this simulation study, we quantitatively evaluated dose distributions based on 4-dimensional CT (4DCT) treatment planning. METHODS Volumetric 4DCTs were acquired for 14 patients with lung tumors. Gross tumor volume, clinical target vo...

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