In the absence of a randomized control trial, regression discontinuity (RD) designs can produce plausible estimates of the treatment effect on an outcome for individuals near a cutoff score. In the standard RD design, individuals with rating scores higher than some exogenously determined cutoff score are assigned to one treatment condition; those with rating scores below the cutoff score are as...

Abstract: Robust design (RD), implemented in statistical and mathematical procedures to simultaneously minimise the process bias and variability, is widely used in many areas of engineering and technology to represent complex real-world industrial settings. For RD modelling and optimisation, response surface methodology (RSM) is often utilised as an estimation method to represent the functional...

The Runt domain (RD) is the DNA-binding region of the Runx genes. A related protein, known as core binding factor beta (CBFbeta) also binds to the RD to enhance RD-DNA interaction by 6- to 10-fold. Here, we report results from molecular dynamics (MD) simulations of RD alone, as a dimer in complexes with DNA and CBFbeta and in a ternary complex with DNA and CBFbeta. Consistent with the experimen...

Mouse mCRY1 and zebrafish zCRY1a and zCRY3 belong to the DNA photolyase/Cryptochrome family. mCRY1 and zCRY1a repress CLOCK:BMAL1-mediated transcription, whereas zCRY3 does not. Reciprocal chimeras between zCRY1a and zCRY3 were generated to determine the zCRY1a regions responsible for nuclear translocation, interaction with the CLOCK:BMAL1 heterodimer, and repression of CLOCK:BMAL1-mediated tra...

Neuroscience has advanced our understanding of the neurological basis of reading disability (RD). Yet, no functional imaging work has been reported on the twice-exceptional dyslexic: individuals exhibiting both non-verbal-giftedness and RD. We compared groups of reading-disabled (RD), non-verbally-gifted (G), non-verbally-gifted-RD (GRD), and control (C) adults on validated word-rhyming and spa...

In the article we settle down the problem of permanence of property RD under group extensions. We show that if 1 → N → G → Q → 1 is a short exact sequence of compactly generated groups such that Q has property RD, and N has property RD with respect to the restriction of a word-length on G, then G has property RD. We also generalize the result of Ji and Schweitzer stating that locally compact gr...