Stepwise one-electron reduction of oxygen to water produces reactive oxygen species (ROS) that are chemically and biochemically similar to reactive sulfide species (RSS) derived from one-electron oxidations of hydrogen sulfide to elemental sulfur. Both ROS and RSS are endogenously generated and signal via protein thiols. Given the similarities between ROS and RSS, we wondered whether extant met...

Ovary is a dynamic organ and generates excess amount of reactive oxygen species (ROS) during follicular growth, development, maturation and ovulation [1]. The increased level of ROS is scavenged by antioxidant systems [2]. A moderate increase of ROS could be beneficial for oocyte meiotic maturation and reproductive outcome [3-5]. Overproduction of ROS or depletion of enzymatic antioxidant syste...

Reactive oxygen species (ROS) are the major factors that induce oxidative modification of DNA and gene mutation. ROS can elicit oxidative stress and affect a wide variety of physiological and pathological processes including embryonal development, maturation and aging.

Increases in reactive oxygen species (ROS) and tissue evidence of oxidative injury are common in patients with inflammatory processes or tissue injury. This has led to many clinical attempts to scavenge ROS and reduce oxidative injury. However, we live in an oxygen rich environment and ROS and their chemical reactions are part of the basic chemical processes of normal metabolism. Accordingly, o...

Reactive oxygen species (ROS) and reactive nitrogen (RNS) play a fundamental role in regulating endothelial function vascular tone the physiological conditions of system. However, oxidative stress has detrimental effects on human health, numerous studies confirmed that high ROS/RNS production contributes to initiation progression cardiovascular diseases. The antioxidant defense an essential hom...

BACKGROUND AND OBJECTIVE: Oxidative stress can be described as a state brought on by an unfavorable rise in the generation of reactive oxygen species (ROS), growth ROS production, or decline antioxidant defense. The study aimed to investigate impact non-surgical periodontal treatment clinical parameters and serum malondialdehyde MDA, total capacity TAOC, oxidant status TOS smokers non-smokers p...

Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil. This study designed to investigate the mechanism of cytotoxicity of MPA on the genetically engineered PC12 Tet Off (PTO) neuronal cells with p53 gene. Alamar Blue (AB) reduction showed concentration-dependent cytotoxicity of MPA on PTO cells with IC50 value of 32.32 ± 4.61 mM. The reactive oxygen species (ROS) generation...

Mycophenolic acid (MPA) is the active metabolite of mycophenolate mofetil. This study designed to investigate the mechanism of cytotoxicity of MPA on the genetically engineered PC12 Tet Off (PTO) neuronal cells with p53 gene. Alamar Blue (AB) reduction showed concentration-dependent cytotoxicity of MPA on PTO cells with IC50 value of 32.32 ± 4.61 mM. The reactive oxygen species (ROS) generation...

infertility is one of the most stressful conditions amongst married couples. male factor infertility is implicated in almost half of these cases. recent advances in the field of reproductive medicine have focused the attention of many researchers to consider reactive oxygen species (ros) as one of the mediators of infertility causing sperm dysfunction. although, ros is involved in many physiolo...