The involvement of C-reactive protein (CRP) in the activation of complement in patients with sepsis was investigated. In 104 patients with infections of varying severity, circulating levels of CRP-complement complexes, which are specific indicators for CRP-mediated complement activation, were assessed. Complement-CRP complexes were increased in almost all patients and correlated significantly w...

Sepsis is the immunological response of systemic inflammation to bacterial, fungal or viral infection. An early diagnosis of sepsis is essential for the successful management of this condition; it allows the prompt administration of appropriate antibiotic regimens and avoidance of unnecessary interventions. A sepsis biomarker must be able to differentiate between bacterial and viral infection, ...

OBJECTIVE We sought to evaluate whether procalcitonin was superior to C-reactive protein in guiding antibiotic therapy in intensive care patients with sepsis. DESIGN Randomized open clinical trial. SETTING Two university hospitals in Brazil. PATIENTS Patients with severe sepsis or septic shock. INTERVENTIONS Patients were randomized in two groups: the procalcitonin group and the C-react...

Procalcitonin (PCT) serum concentration increases abnormally in bacteremia, severe sepsis and septic shock and was described as an inflamation-induced protein. The aim of this study is to evaluate the clinical application of PCT-Q test for determination procalcitonin (PCT) serum level in patients with suspected sepsis. Fifty six patients according the criteria for sepsis (ACCP/SCCM,1992) and 19...

BACKGROUND High levels of tumor necrosis factor (TNF) alpha messenger RNAs and interleukin (IL) 8 have been reported in leukocytes of patients with sepsis. HYPOTHESIS Assessment of leukocyte intracytoplasmic levels of proinflammatory and anti-inflammatory cytokines might be clinically more relevant to determine prognosis in patients with severe sepsis. DESIGN Cohort study. SETTING Surgica...

BACKGROUND The early detection of circulatory failure in patients with sepsis is important for successful treatment. Heparin-binding protein (HBP), released from activated neutrophils, is a potent inducer of vascular leakage. In this study, we investigated whether plasma levels of HBP could be used as an early diagnostic marker for severe sepsis with hypotension. METHODS A prospective study o...

We studied the usefulness of serum procalcitonin (PCT), interleukin-6 (IL-6), lipopolysaccharide binding protein (LBP) levels and C-reactive protein (CRP) levels, in differentiating between systemic inflammatory response syndrome (SIRS) and sepsis in critically ill patients. Methods. In this single centre prospective observational study we included all consecutive patients admitted with SIRS or...

OBJECTIVES In the last few years, serum procalcitonin has been proposed as an early marker of infections in neonates, with varying results. In this study, we aimed to investigate the value of procalcitonin, and C- reactive protein in establishing the diagnosis of neonatal sepsis. MATERIALS AND METHODS Blood samples were collected at admission from 69 neonates with suspected infection (admitte...

Abstract Background Neonates with sepsis may have concurrent urinary tract infection (UTI), which be asymptomatic or nonspecific symptoms. Failure to diagnose UTI, resulting in a delay of appropriate therapy, has been reported cause renal scarring, hypertension, and kidney failure among infants. This study aimed determine the contribution UTI neonatal assess different risk factors that could as...

background multiple population-based human studies have established a strong association between increasing levels of serum c-reactive protein, uric acid and subsequent development of hypertension. objectives we aimed to investigate the association between mental well-being with presence of hypertension, hyperuricemia and hs-crp levels. ‬‬ patients and methods this was a cross sectional study o...