Mitochondria import most of their resident proteins from the cytosol, and the import receptor Tom20 of the outer-membrane translocator TOM40 complex plays an essential role in specificity of mitochondrial protein import. Here we analyzed the effects of Tom20 binding on NMR spectra of a long mitochondrial presequence and found that it contains two distinct Tom20-binding elements. In vitro import...

Porin, also termed the voltage-dependent anion channel, is the most abundant protein of the mitochondrial outer membrane. The process of import and assembly of the protein is known to be dependent on the surface receptor Tom20, but the requirement for other mitochondrial proteins remains controversial. We have used mitochondria from Neurospora crassa and Saccharomyces cerevisiae to analyze the ...

The RanGTP-binding nuclear transport receptors transportin1 (TRN1) and transportin2 (TRN2) are highly similar in sequence but are reported to function in nuclear import and export, respectively. Here we show that TRN2 possesses properties of a nuclear import receptor. TRN1/2 both interacted with a similar set of RNA-binding proteins in a RanGTP-sensitive manner. TRN2 bound RanGTP with high affi...

In the present study Iran’s rice imports trend is forecasted, using artificial neural networks and econometric methods, during 2009 to 2013, and their results are compared. The results showed that feet forward neural network leading with less forecast error and had better performance in comparison to econometric techniques and also, other methods of neural networks, such as Recurrent networks a...

The TIM23 complex mediates translocation of proteins across, and their lateral insertion into, the mitochondrial inner membrane. Translocation of proteins requires both the membrane-embedded core of the complex and its ATP-dependent import motor. Insertion of some proteins, however, occurs in the absence of ATP, questioning the need for the import motor during lateral insertion. We show here th...

in recent years, iran has experienced high level depreciation of the nominal exchange rate (ner). the ultimate effects of such depreciation on iranian families’ welfare and income distribution have been a challenging issue among policymakers and researchers. accordingly, this study evaluates the economic effects of ner depreciation on the rice market, using spatial price equilibrium model. the ...

according to endogenous tariff hypothesis, tariff is endogenously determined by the set of political economy factors. using the co- integrated var approach and in the framework of the hypothesis, the present study examined the determinants of tariff protection in iran over the period 1971-2010. based on the results, though no evidence has been obtained about the impact of unemployment and impor...

1 For example, A. R. Lacey, "Quantifier Words", in A. R. Lacey.vi Dictionary of Philosophy (Charles Scribner's Sons, N. Y.: 1976); Alex Orenstein, Existence and the Particular Quantifier (Temple U. Press, Philadelphia: 1978), pp. 105-07; Baruch Brody, "Glossary of Logical Terms", Encyclopedia of Philosophy, Vol. 5 (Macmillan, N. Y.: 1967), p. 64; Antony Flew, "Existential Import", in Antony Fle...

Clinical data warehouses are used to consolidate all available clinical data from one or multiple organizations. They represent an important source for clinical research, quality management and controlling. Since its introduction, the data warehouse i2b2 gathered a large user base in the research community. Yet, little work has been done on the process of importing clinical data into data wareh...

The Saccharomyces cerevisiae F1-ATPase beta subunit precursor contains redundant mitochondrial protein import information at its NH2 terminus (D. M. Bedwell, D. J. Klionsky, and S. D. Emr, Mol. Cell. Biol. 7:4038-4047, 1987). To define the critical sequence and structural features contained within this topogenic signal, one of the redundant regions (representing a minimal targeting sequence) wa...