Quantitative trait loci (QTLs) underlying multifactorial disorders explain little of the heritability - most is 'missing'. A new yeast study has identified QTLs which explain most heritability in traits. Why is heritability missing in human diseases but not here?

ROM HARRE, Great scientific experiments, Oxford, Phaidon Press, 1981, 8vo, pp. 224, illus., £8.95. In little more than 200 pages Dr. Harre manages to describe the reasoning behind twenty experiments, the apparatus involved, and the results. They cover a wide range of sciences distributed between Aristotle's biology and quantum mechanics. The amount of information included is remarkable. For exa...

We design adaptive realized kernels to estimate the integrated volatility in a framework that combines a stochastic volatility model with leverage effect for the effi cient price and a semiparametric microstructure noise model specified at the highest frequency. Some time dependence parameters of the noise model must be estimated before adaptive realized kernels can be implemented. We study the...

This paper introduces a new multivariate conditional volatility model for returns that utilizes realized covariance matrices. The model decomposes the conditional and realized covariance matrices into standard deviations and correlations matrices. On a first level, the univariate variances are estimated by a modified Generalized Autoregressive Conditional Heteroskedasticity (GARCH) that exploit...

We will in some places restrict attention to puts, by put-call parity: for realized variance options, a long-call short-put combination pays [X]T −Q, equal to a Q-strike variance swap; and for realized volatility options, a long-call short-put combination pays [X] T − Q1/2, equal to a Q1/2-strike volatility swap. Unlike variance swaps [EQF07/024, EQF07/045], which admit exact model-free (assumi...

OBJECTIVES Pulse pressure (PP) is a measure of large artery stiffness and has been shown to be an important predictor of cardiovascular morbidity and mortality. The aims of the present study were to investigate the heritability of PP in three studies, the Diabetes Heart Study (DHS), the Insulin Resistance Atherosclerosis Family Study (IRAS FS), and the NHLBI Family Heart Study (FHS), to estimat...

Since Tysk et al's pioneering analysis of the Swedish twin registry, twin and family studies continue to support a strong genetic basis of the inflammatory bowel diseases. The coefficient of heritability for siblings of inflammatory bowel disease probands is 25 to 42 for Crohn's disease and 4 to 15 for ulcerative colitis. Heritability estimates for Crohn's disease and ulcerative colitis from po...

This study investigated heritability for bovine growth estimated with genomewide single nucleotide polymorphism (SNP) information obtained from a DNA microarray chip. Three hundred sixty seven Korean cattle were genotyped with the Illumina BovineSNP50 BeadChip, and 39,112 SNPs of 364 animals filtered by quality assurance were analyzed to estimate heritability of body weights at 6, 9, 12, 15, 18...

Body weight (BW) records (n=11,659) of 4961 Kurdi sheep from 215 sires and 2085 dams were used to estimate the additive genetic, direct and maternal permanent environmental effects on growth from 1 to 300 days of age. The data were collected from 1993 to 2015 at a breeding station in North Khorasan province; Iran. Genetic parameters for growth traits were estimated using random regression test-...

The concept of species-level heritability is widely contested. Because it is most likely to apply to emergent, species-level traits, one of the central discussions has focused on the potential heritability of geographic range size. However, a central argument against range-size heritability has been that it is not compatible with the observed shape of present-day species range-size distribution...