While most genes in the mammalian genome are transcribed from both parental chromosomes in cells where they are expressed, approximately 10% of genes are expressed monoallelically, so that any given cell will express either the paternal or maternal allele, but not both. The antigen receptor genes in B and T cells are well-studied examples of a gene family, which is expressed in a monoallelic ma...

Recent evidence suggests that lymphocyte Ag receptor gene rearrangement does not always stop after the expression of the first productively rearranged receptor. Light chain gene rearrangement in B cells, and alpha-chain rearrangement in T cells can continue, which raises the question: how is allelic exclusion maintained, if at all, in the face of continued rearrangement? In this and the accompa...

Virus-transformed pre-B cells undergo ordered immunoglobulin (Ig) gene rearrangements during culture. We devised a series of highly sensitive polymerase chain reaction assays for Ig gene rearrangement and unrearranged Ig gene segment transcription to study both the possible relationship between these processes in cultured pre-B cells and the role played by heavy (H) chain (mu) protein in regula...

Note taking is a fundamental activity for learning, and many software tools which enable students to take digitized notes have been proposed. Digitized notes are advantageous because they can be easily edited, rearranged, and shared. Although many note-taking tools have been proposed, there has been little research to examine the effect of note rearrangement with a digitized tool in terms of kn...

A numerical method for passive scalar and self-advection dynamics, Lagrangian rearrangement, is proposed. This fully Lagrangian advection algorithm introduces no artificial numerical dissipation or interpolation of parcel values. In the zero-viscosity limit, it preserves all of the Casimir invariants associated with parcel rearrangement. In the twodimensional case presented here, these invarian...

The Rockefeller University Press $30.00 J. Exp. Med. Vol. 205 No. 13 2985-2994 www.jem.org/cgi/doi/10.1084/jem.20082053 2985 B cells undergo a random process of V(D)J recombination to generate the many distinct receptors needed to recognize a vast array of antigens. An inevitable consequence of this random process is the production of autoreactive B cells ( 1 ). An important mechanism for toler...

An interacting-rearrangement model for sheared solids shows multiple interaction-encoding memories and complex limit cycles.