PURPOSE The genetic alterations in biliary tract cancer and clinicopathological associations have not been studied in large population-based studies. EXPERIMENTAL DESIGN We evaluated genetic alterations such as K-ras mutation, p53 overexpression, microsatellite instability (MSI), and alterations of the polyadenine tract present in the transforming growth factor beta receptor type II (TGFbetaR...

The prognosis of breast cancer in pre-menopausal women is very variable and dependent on the interactions several biological factors. androgen receptor (AR) could be among prognostic variables related to survival although data scarce. aim study was examine relationship between expression outcomes estrogen (ER)-positive invasive carcinoma patients. We assessed AR ER-positive carcinomas correlate...

Fms-like tyrosine kinase 3 (Flt3) is an important growth factor receptor in hematopoiesis. Gain-of-function mutations of the receptor contribute to the transformation of acute myeloid leukemia (AML). Src-like adaptor protein (SLAP) is an interaction partner of the E3 ubiquitin ligase Cbl that can regulate receptor tyrosine kinases-mediated signal transduction. In this study, we analyzed the rol...

these experiments examined the effects of pre-test intra dorsal hippocampus (intra-ca1) administration of gabaa receptor agonist and antagonist, muscimol and bicuculline respectively, on state-dependent learning induced by lithium. male nmri mice were trained in a one-trial step-down inhibitory avoidance task, and immediately after training they received ip injections of either saline (10 ml/kg...

Introduction: The etiology of male breast cancer is unclear, but hormonal levels may play a role in development of this disease. It seems that the risk of male breast cancer related to increased lifelong exposure to estrogen or reduced androgen. The aim of this study was to investigate the expression of the steroid hormone receptors including estrogen receptor (ER) and progesterone receptor (PR...

Background and objectivesThe overexpression mutation of EGFRs are associated with various types human cancers. Epidermal growth factor receptor variant III (EGFRvIII) is one the most notable EGFR mutations, exclusively present in cancer cells, making it a potential therapeutic target. The study aims to determine whether recombinant immunotoxin 86 (rIT86) can effectively kill EGFRvIII-expressing...

In the present study, the effect of GABA (γ-aminobutyric acid) receptor agonists and antagonists on morphine-induced antinociception was investigated in formalin test in rats. Intraperitoneal (i.p.) injection of different doses of morphine (1, 3, 6 and 9 mg/kg) and intracerebroventricular (i.c.v.) injection of different doses of muscimol (0.5, 1 and 2 g/rat) or baclofen (0.25, 0.5 and 1 g/rat) ...

Insulin-like growth factor binding protein 3 (IGFBP-3) is an important regulator of normal and malignant cell growth. It modulates the mitogenic effects of insulin-like growth factors (IGFs) by inhibiting growth through mechanisms both dependent on and independent of IGF binding. IGF-I and IGF-II levels are regulated by binding to the IGF-II receptor, which is inactivated by mutation in human g...

Estrogen, progesterone, and HER2 receptor-negative triple-negative breast cancers encompass the most clinically challenging subtype for which targeted therapeutics are lacking. We find that triple-negative tumors exhibit elevated MYC expression, as well as altered expression of MYC regulatory genes, resulting in increased activity of the MYC pathway. In primary breast tumors, MYC signaling did ...